Synthesis, purification, and structural characterization of the dimethyldiselenoarsinate anion

Jurgen Gailer, Graham N. George, Hugh H. Harris, Ingrid J. Pickering, Roger C. Prince, Arpad Somogyi, Gavin A. Buttigieg, Richard S. Glass, M. Bonner Denton

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

A novel arsenic-selenium solution species was synthesized by reacting equimolar sodium selenite and sodium dimethylarsinate with 10 mol equiv of glutathione (pH 7.5) in aqueous solution. The solution species showed a single 77Se NMR resonance at 112.8 ppm. Size-exclusion chromatography (SEC) using an inductively coupled plasma atomic emission spectrometer (ICP-AES) as the simultaneous arsenic-, selenium-, sulfur-, and carbon-specific detector revealed an arsenic-selenium moiety with an As:Se molar ratio of 1:2. Electrospray ionization mass spectrometry (ESI-MS) of the chromatographically purified compound showed a molecular mass peak at m/z 263 in the negative ion mode. Fragmentation of the parent ion (ESI-MS-MS) produced (CH3)2As- and Se2-fragments. Arsenic and selenium extended X-ray absorption fine structure spectroscopy (EXAFS) of the purified species revealed two As-C interactions at 1.943 Å and two As-Se interactions at 2.279 Å. On the basis of these results this novel solution species is identified as the dimethyldiselenoarsinate anion.

Original languageEnglish (US)
Pages (from-to)5426-5432
Number of pages7
JournalInorganic Chemistry
Volume41
Issue number21
DOIs
StatePublished - Oct 21 2002

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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    Gailer, J., George, G. N., Harris, H. H., Pickering, I. J., Prince, R. C., Somogyi, A., Buttigieg, G. A., Glass, R. S., & Denton, M. B. (2002). Synthesis, purification, and structural characterization of the dimethyldiselenoarsinate anion. Inorganic Chemistry, 41(21), 5426-5432. https://doi.org/10.1021/ic0113146