Synthesis, X-ray absorption spectroscopy and purification of the seleno-bis (S-glutathionyl) arsinium anion from selenide, arsenite and glutathione

Jürgen Gailer, Graham N. George, Ingrid J. Pickering, Gavin A. Buttigieg, M. Bonner Denton, Richard S. Glass

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We report a new synthesis of the seleno-bis (S-glutathionyl) arsinium anion, [(GS)2AsSe]-. An aqueous solution of bis-glutathionylarsenous acid. (GS)2As-OH, prepared form stoichiometric glutathione and arsenite, was reacted in situ with a solution of sodium hydrogen selenide, prepared from elemental selenium and sodium borohydride. Analysis of the arsenic and selenium K-edge X-ray absorption spectra indicated virtually quantitative formation of [(GS)2AsSe]- with As Se and As-S distances of 2.31 and 2.25 Å, respectively, and the concentrated sample allowed a definitive X-ray spectroscopic characterization. Size-exclusion chromatography was used to separate [(GS)2AsSe]- from residual borate in the reaction mixture.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalJournal of Organometallic Chemistry
Volume650
Issue number1-2
DOIs
StatePublished - May 1 2002

Keywords

  • Arsinium anion
  • S-glutathionyl
  • Size-exclusion chromatography
  • X-ray absorption spectroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Synthesis, X-ray absorption spectroscopy and purification of the seleno-bis (S-glutathionyl) arsinium anion from selenide, arsenite and glutathione'. Together they form a unique fingerprint.

  • Cite this