Systemic delivery of insulin via an enhancer-free ocular device

Yung Chi Lee, Pahala Simamora, Samuel H. Yalkowsky

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Sodium insulin and zinc insulin ocular devices are developed for the systemic delivery of insulin. The devices consist of Gelfoam (absorbable gelatin sponge, USP) as an insulin carrier and do not contain any surfactant or absorption enhancer. Sodium insulin was dissolved in either distilled water, 30% ethanol, or 10% acetic acid for either eyedrop or device preparations. Because of its low solubility in water and aqueous ethanol solution, zinc insulin was dissolved in 10% acetic acid-water solution for eye devices preparation. Commercially availabile Humulin R was selected as another source of zinc insulin and was used as an eyedrop as well as one device preparation. Only 10% acetic acid solution-treated insulin devices produce significant blood glucose reduction. The dose of insulin used in this study is <50% of that used in the reported insulin devices.

Original languageEnglish (US)
Pages (from-to)1361-1364
Number of pages4
JournalJournal of pharmaceutical sciences
Volume86
Issue number12
DOIs
StatePublished - Dec 1997

ASJC Scopus subject areas

  • Pharmaceutical Science

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