Systemic lupus erythematosus and sickle hemoglobinopathies

A report of two cases and review of the literature

Emmanuel Katsanis, E. Hsu, K. H. Luke, J. A. McKee

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Two adolescent black females with sickel cell disease who developed systemic lupus erythematosus (SLE) are presented. The recognition of SLE was delayed because all new symptoms were initially attributed to their underlying sickle cell disease. Nine similar cases have been previously reported. The hypothesis that a deficiency of the alternative complement pathway in some patients with sickle hemoglobinopathies predisposes them toward immune complex disorders was not confirmed in our study. Our first patient had normal and our second increased activity of the alternative pathway of complement activation.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalAmerican Journal of Hematology
Volume25
Issue number2
StatePublished - 1987
Externally publishedYes

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Alternative Complement Pathway
Hemoglobinopathies
Systemic Lupus Erythematosus
Immune System Diseases
Sickle Cell Anemia
Antigen-Antibody Complex

ASJC Scopus subject areas

  • Hematology

Cite this

Systemic lupus erythematosus and sickle hemoglobinopathies : A report of two cases and review of the literature. / Katsanis, Emmanuel; Hsu, E.; Luke, K. H.; McKee, J. A.

In: American Journal of Hematology, Vol. 25, No. 2, 1987, p. 211-214.

Research output: Contribution to journalArticle

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