Systemic lupus erythematosus and sickle hemoglobinopathies: A report of two cases and review of the literature

Emmanuel Katsanis, Elizabeth Hsu, Koon‐Hung ‐H Luke, James A. McKee

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Two adolescent black females with sickle cell disease who developed systemic lupus erythematosus (SLE) are presented. The recognition of SLE was delayed because all new symptoms were initially attributed to their underlying sickle cell disease. Nine similar cases have been previously reported. The hypothesis that a deficiency of the alternative complement pathway in some patients with sickle hemoglobinopathies predisposes them toward immune complex disorders was not confirmed in our study. Our first patient had normal and our second increased activity of the alternative pathway of complement activation.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalAmerican Journal of Hematology
Volume25
Issue number2
DOIs
StatePublished - Jun 1987
Externally publishedYes

Keywords

  • alternative complement pathway
  • immune complex diseases
  • sickle cell disease

ASJC Scopus subject areas

  • Hematology

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