Systemic lupus erythematosus in three ethnic groups: III. A comparison of characteristics early in the natural history of the LUMINA cohort

G. S. Alarcón, A. W. Friedman, K. V. Straaton, J. M. Moulds, J. Lisse, H. M. Bastian, G. McGwin, A. A. Bartolucci, J. M. Roseman, J. D. Reveille

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236 Scopus citations

Abstract

Aim: To determine and contrast the socioeconomic-demographic and clinical features of patients with recent onset (≤ 5 y) systemic lupus erythematosus (SLE) from three ethnic groups, Hispanic, African-American and Caucasian (H, AA, C). Subjects and methods: SLE cases (American College of Rheumatology criteria) (incident (n = 56), prevalent (n = 173)), were enrolled in a longitudinal study at The University of Alabama at Birmingham, The University of Texas-Houston Health Science Center and The University of Texas Medical Branch at Galveston. Socioeconomic-demographic, clinical, immunological, behavioral and psychological data were obtained using validated instruments and standard laboratory techniques, and compared. Results: 70 H, 88 AA and 71 C SLE patients constitute this cohort. H and AA patients were younger and of lower socioeconomic-demographic status. They also had evidence of more frequent organ system involvement (renal, cardiovascular), more auto-antibodies, more active disease (after adjusting for discrepant socioeconomic-demographic features), lower levels of social support and more abnormal illness-related behaviors (more in H than in AA). H also were more likely to have an abrupt disease onset; C were more likely to be on antimalarials but less likely to be on corticosteroids. H, AA, and C used health care resources comparably. They had similar levels of pain and physical and mental functioning after adjusting for age, disease duration, income, education, social support, illness-related behaviors, and Systemic Lupus Activity Measure or SLAM scores. Conclusions: H and AA patients have more active SLE, at an earlier age of onset, and a less favorable socioeconomic-demographic structure (worse among the H than AA) which predispose them to a less favorable natural history.

Original languageEnglish (US)
Pages (from-to)197-209
Number of pages13
JournalLupus
Volume8
Issue number3
DOIs
StatePublished - 1999

Keywords

  • African-American
  • Caucasian
  • Hispanic
  • Lupus
  • Outcome
  • Socioeconomic

ASJC Scopus subject areas

  • Rheumatology

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