Systemic sclerosis in 3 US ethnic groups: A comparison of clinical, sociodemographic, serologic, and immunogenetic determinants

John D. Reveille, Michael Fischbach, Terry McNearney, Alan W. Friedman, Martha B. Aguilar, Jeffrey R Lisse, Marvin J. Fritzler, Chul Ahn, Frank C. Arnett

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Objective: To determine whether ethnic factors influence the presentation, serologic expression and immunogenetics of systemic sclerosis (SSc), patients from 3 ethnic groups were compared for clinical features, SSc-associated autoantibodies, and human leukocyte antigen (HLA) class II alleles. Methods: Fifty-four Hispanics, 28 African Americans, and 79 whites from Texas with recent-onset (less than 5 years) SSc enrolled in a prospective longitudinal study were assessed for sociodemographic, clinical, immunologic, immunogenetic, behavioral, and psychologic parameters using validated instruments and standard laboratory techniques. Serologic and immunogenetic characteristics from these patients and larger retrospective SSc cohorts of the same ethnic groups also were examined. Results: Hispanics and African Americans in the prospective cohort were more likely to have diffuse skin involvement, skin pigmentary changes, digital ulcers, pulmonary hypertension (African Americans), and an overall lower sociodemographic status than whites, who had more facial telangiectasia and hypothyroidism. In the larger combined prospective and retrospective groups of SSc patients, whites were likely to have more anticentromere antibodies (ACA) and African Americans more anti-U1-ribonucleoprotein (RNP) and anti-U3-RNP (fibrillarin) autoantibodies. HLA-DQB1*0301 was significantly associated with SSc per se in all 3 ethnic groups; HLA-DRB1*11 correlated with the anti-topoisomerase I antibody response, and HLA-DRB1*01, DRB1*04, and DQB1*0501 with ACA. Conclusions: Important sociodemographic, clinical, and serologic differences exist between whites, African Americans, and Hispanics, despite shared genetic (HLA class II) predisposing factors. The impact of these differences on prognosis remain to be determined.

Original languageEnglish (US)
Pages (from-to)332-346
Number of pages15
JournalSeminars in Arthritis and Rheumatism
Volume30
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

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Immunogenetics
Systemic Scleroderma
Ethnic Groups
HLA Antigens
African Americans
Hispanic Americans
Ribonucleoproteins
Autoantibodies
Telangiectasis
Type I DNA Topoisomerase
Skin
Hypothyroidism
Pulmonary Hypertension
Causality
Ulcer
Antibody Formation
Longitudinal Studies
Alleles
Prospective Studies

Keywords

  • Autoantibodies
  • Ethnicity
  • Immunogenetics
  • Scleroderma
  • Sociodemographic factors
  • Systemic sclerosis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Systemic sclerosis in 3 US ethnic groups : A comparison of clinical, sociodemographic, serologic, and immunogenetic determinants. / Reveille, John D.; Fischbach, Michael; McNearney, Terry; Friedman, Alan W.; Aguilar, Martha B.; Lisse, Jeffrey R; Fritzler, Marvin J.; Ahn, Chul; Arnett, Frank C.

In: Seminars in Arthritis and Rheumatism, Vol. 30, No. 5, 2001, p. 332-346.

Research output: Contribution to journalArticle

Reveille, JD, Fischbach, M, McNearney, T, Friedman, AW, Aguilar, MB, Lisse, JR, Fritzler, MJ, Ahn, C & Arnett, FC 2001, 'Systemic sclerosis in 3 US ethnic groups: A comparison of clinical, sociodemographic, serologic, and immunogenetic determinants', Seminars in Arthritis and Rheumatism, vol. 30, no. 5, pp. 332-346. https://doi.org/10.1053/sarh.2001.20268
Reveille, John D. ; Fischbach, Michael ; McNearney, Terry ; Friedman, Alan W. ; Aguilar, Martha B. ; Lisse, Jeffrey R ; Fritzler, Marvin J. ; Ahn, Chul ; Arnett, Frank C. / Systemic sclerosis in 3 US ethnic groups : A comparison of clinical, sociodemographic, serologic, and immunogenetic determinants. In: Seminars in Arthritis and Rheumatism. 2001 ; Vol. 30, No. 5. pp. 332-346.
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T2 - A comparison of clinical, sociodemographic, serologic, and immunogenetic determinants

AU - Reveille, John D.

AU - Fischbach, Michael

AU - McNearney, Terry

AU - Friedman, Alan W.

AU - Aguilar, Martha B.

AU - Lisse, Jeffrey R

AU - Fritzler, Marvin J.

AU - Ahn, Chul

AU - Arnett, Frank C.

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KW - Sociodemographic factors

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