T cell aging: Naive but not young

Research output: Contribution to journalReview article

73 Scopus citations

Abstract

The immune system exhibits profound age-related changes, collectively termed immunosenescence. The most visible of these is the decline in protective immunity, which results from a complex interaction of primary immune defects and compensatory homeostatic mechanisms. The sum of these changes is a dysregulation of many processes that normally ensure optimal immune function. Recent advances suggest that old mice can produce fully functional new T cells, opening both intriguing inquiry avenues and raising critical questions to be pursued.

Original languageEnglish (US)
Pages (from-to)837-840
Number of pages4
JournalJournal of Experimental Medicine
Volume201
Issue number6
DOIs
StatePublished - Mar 21 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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