T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1

Malika Trad, Alexandrine Gautheron, Jennifer Fraszczak, Darya Alizadeh, Claire B Larmonier, Collin J. Lacasse, Sara Centuori, Sylvain Audia, Maxime Samson, Marion Ciudad, Francis Bonnefoy, Stéphanie Lemaire-Ewing, Emmanuel Katsanis, Sylvain Perruche, Philippe Saas, Bernard Bonnotte

Research output: Contribution to journalArticle

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Abstract

T lymphocytes activated by dendritic cells (DC) which present tumor antigens play a key role in the antitumor immune response. However, in patients suffering from active cancer, DC are not efficient at initiating and supporting immune responses as they participate to T lymphocyte inhibition. DC in the tumor environment are functionally defective and exhibit a characteristic of immature phenotype, different to that of DC present in nonpathological conditions. The mechanistic bases underlying DC dysfunction in cancer responsible for the modulation of T-cell responses and tumor immune escape are still being investigated. Using two different mouse tumor models, we showed that tumor-infiltrating DC (TIDC) are constitutively immunosuppressive, exhibit a semimature phenotype, and impair responder T lymphocyte proliferation and activation by a mechanism involving CD39 ectoenzyme.

Original languageEnglish (US)
Article number891236
JournalBioMed Research International
Volume2015
DOIs
StatePublished - 2015

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Arginase
T-cells
Dendritic Cells
Tumors
T-Lymphocytes
Neoplasms
Tumor Escape
Phenotype
Neoplasm Antigens
Immunosuppressive Agents
Lymphocyte Activation
ectoATPase
Chemical activation
Modulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1. / Trad, Malika; Gautheron, Alexandrine; Fraszczak, Jennifer; Alizadeh, Darya; Larmonier, Claire B; Lacasse, Collin J.; Centuori, Sara; Audia, Sylvain; Samson, Maxime; Ciudad, Marion; Bonnefoy, Francis; Lemaire-Ewing, Stéphanie; Katsanis, Emmanuel; Perruche, Sylvain; Saas, Philippe; Bonnotte, Bernard.

In: BioMed Research International, Vol. 2015, 891236, 2015.

Research output: Contribution to journalArticle

Trad, M, Gautheron, A, Fraszczak, J, Alizadeh, D, Larmonier, CB, Lacasse, CJ, Centuori, S, Audia, S, Samson, M, Ciudad, M, Bonnefoy, F, Lemaire-Ewing, S, Katsanis, E, Perruche, S, Saas, P & Bonnotte, B 2015, 'T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1', BioMed Research International, vol. 2015, 891236. https://doi.org/10.1155/2015/891236
Trad, Malika ; Gautheron, Alexandrine ; Fraszczak, Jennifer ; Alizadeh, Darya ; Larmonier, Claire B ; Lacasse, Collin J. ; Centuori, Sara ; Audia, Sylvain ; Samson, Maxime ; Ciudad, Marion ; Bonnefoy, Francis ; Lemaire-Ewing, Stéphanie ; Katsanis, Emmanuel ; Perruche, Sylvain ; Saas, Philippe ; Bonnotte, Bernard. / T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1. In: BioMed Research International. 2015 ; Vol. 2015.
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abstract = "T lymphocytes activated by dendritic cells (DC) which present tumor antigens play a key role in the antitumor immune response. However, in patients suffering from active cancer, DC are not efficient at initiating and supporting immune responses as they participate to T lymphocyte inhibition. DC in the tumor environment are functionally defective and exhibit a characteristic of immature phenotype, different to that of DC present in nonpathological conditions. The mechanistic bases underlying DC dysfunction in cancer responsible for the modulation of T-cell responses and tumor immune escape are still being investigated. Using two different mouse tumor models, we showed that tumor-infiltrating DC (TIDC) are constitutively immunosuppressive, exhibit a semimature phenotype, and impair responder T lymphocyte proliferation and activation by a mechanism involving CD39 ectoenzyme.",
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AU - Lacasse, Collin J.

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AU - Samson, Maxime

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AU - Bonnefoy, Francis

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AU - Bonnotte, Bernard

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