T-lymphocyte predominance in lesions of canine Coccidioidomycosis

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Abstract

Coccidioidomycosis is a systemic fungal infection endemic to the southwestern United States. Although cell-mediated immunity is considered critical in control of the infection, little is known of the cellular population in naturally occurring lesions. To characterize the lymphocytic infiltration, archived formalin-fixed, paraffin-embedded tissues (subcutis, pericardium/heart, lung, bone, and synovium) from 18 dogs with coccidioidomycosis were studied with immunohistochemistry for CD3 and CD79a. In nearly all lesions, T lymphocytes were more numerous than B lymphocytes and were distributed throughout the lesion with concentration in the periphery of granulomas, whereas B lymphocytes were mostly confined to the periphery of granulomas. The predominance of T lymphocytes in lesions of canine coccidioidomycosis was independent of the tissue evaluated, the number of intralesional organisms, and the nature or severity of the inflammatory response.

Original languageEnglish (US)
Pages (from-to)1008-1011
Number of pages4
JournalVeterinary pathology
Volume48
Issue number5
DOIs
StatePublished - Sep 1 2011

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Keywords

  • CD3
  • Coccidioides
  • coccidioidomycosis
  • dogs
  • immunohistochemistry
  • lymphocytes

ASJC Scopus subject areas

  • veterinary(all)

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