T lymphocyte response to H-2 mutants

Cytotoxic effectors are Ly-1 +2 +

P. J. Wettstein, D. W. Bailey, L. E. Mobraaten, J. Klein, Jeffrey A Frelinger

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2K(ba) and H-2D(da) alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis is demonstrated that the mutant-specific T cells were Ly-1 +2 +. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1 +2 +, demonstrated that Ly-1 +2 + T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of response T cells.

Original languageEnglish (US)
Pages (from-to)3455-3459
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number7
DOIs
StatePublished - 1979
Externally publishedYes

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Isoantigens
T-Lymphocytes
Lymphocytes
Ly Antigens
Phenotype
Differentiation Antigens
Serum

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

T lymphocyte response to H-2 mutants : Cytotoxic effectors are Ly-1 +2 +. / Wettstein, P. J.; Bailey, D. W.; Mobraaten, L. E.; Klein, J.; Frelinger, Jeffrey A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 76, No. 7, 1979, p. 3455-3459.

Research output: Contribution to journalArticle

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abstract = "The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2K(ba) and H-2D(da) alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis is demonstrated that the mutant-specific T cells were Ly-1 +2 +. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1 +2 +, demonstrated that Ly-1 +2 + T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of response T cells.",
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T2 - Cytotoxic effectors are Ly-1 +2 +

AU - Wettstein, P. J.

AU - Bailey, D. W.

AU - Mobraaten, L. E.

AU - Klein, J.

AU - Frelinger, Jeffrey A

PY - 1979

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N2 - The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2K(ba) and H-2D(da) alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis is demonstrated that the mutant-specific T cells were Ly-1 +2 +. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1 +2 +, demonstrated that Ly-1 +2 + T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of response T cells.

AB - The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2K(ba) and H-2D(da) alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis is demonstrated that the mutant-specific T cells were Ly-1 +2 +. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1 +2 +, demonstrated that Ly-1 +2 + T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of response T cells.

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