Tamoxifen therapy in recurrent epithelial ovarian carcinoma

Sheldon A. Weiner, David S. Alberts, Earl A. Surwit, John Davis, David Grosso

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Thirty-seven patients with recurrent epithelial ovarian carcinoma were entered into a trial of tamoxifen therapy (10 mg BID) to determine the effect on long-term survival. Thirty-one patients were evaluable with follow-up ranging from 6 to 42 months since initiation of hormonal therapy. All patients were heavily pretreated with multiple chemotherapeutic regimens (median 3). There was 1 complete responder (3.2%), 2 31 (6.4%) had a partial response, 6 31 (19.3%) had stable disease, and 22 31 (71%) had progressive disease. Twenty-four patients are dead (23 from advanced carcinoma, 1 from cardiac causes); 5 patients are alive with disease; 2 patients are lost to follow-up. Median survival of nonresponders was 7 months versus 16 months for responders (CR + PR + stable disease) (P = 0.001 life table analysis). Of the 9 responders, 7 had poorly differentiated tumors (grades 3 or 4), and 2 had moderately differentiated tumors (grade 2). Eleven patients had estrogen and progesterone receptor studies (ER, PR). No correlation between response rate and receptor status was evident. We conclude that although significant disease regression is unlikely to result from tamoxifen therapy, there may be a subset of patients who can benefit from the cytostatic properties of hormonal manipulation.

Original languageEnglish (US)
Pages (from-to)208-213
Number of pages6
JournalGynecologic oncology
Volume27
Issue number2
DOIs
StatePublished - Jun 1987

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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