Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease [14]

Marcia M. Shull, Ilona Ormsby, Ann B. Kier, Sharon Pawlowski, Ronald J. Diebold, Moying Yin, Ruth Allen, Charles Sidman, Gabriele Proetzel, Dawn Calvin, Nikki Annunziata, Thomas Doetschman

Research output: Contribution to journalArticle

2415 Scopus citations

Abstract

Transforming growth factor-β1 (TGF-β1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-β1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-β1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-β1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.

Original languageEnglish (US)
Pages (from-to)693-699
Number of pages7
JournalNature
Volume359
Issue number6397
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this

Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., Annunziata, N., & Doetschman, T. (1992). Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease [14]. Nature, 359(6397), 693-699. https://doi.org/10.1038/359693a0