Targeting T-type/CaV3.2 channels for chronic pain

Song Cai, Kimberly Gomez, Aubin Moutal, Rajesh Khanna

Research output: Contribution to journalReview articlepeer-review

Abstract

T-type calcium channels regulate neuronal excitability and are important contributors of pain processing. CaV3.2 channels are the major isoform expressed in nonpeptidergic and peptidergic nociceptive neurons and are emerging as promising targets for pain treatment. Numerous studies have shown that CaV3.2 expression and/or activity are significantly increased in spinal dorsal horn and in dorsal root ganglia neurons in different inflammatory and neuropathic pain models. Pharmacological campaigns to inhibit the functional expression of CaV3.2 for treatment of pain have focused on the development of direct channel blockers, but none have produced lead candidates. Targeting the proteins that regulate the trafficking or transcription, and the ones that modify the channels via post-translational modifications are alternative means to regulate expression and function of CaV3.2 channels and hence to develop new drugs to control pain. Here we synthesize data supporting a role for CaV3.2 in numerous pain modalities and then discuss emerging opportunities for the indirect targeting of CaV3.2 channels.

Original languageEnglish (US)
JournalTranslational Research
DOIs
StateAccepted/In press - 2021

Keywords

  • CaV3.2
  • Ubiquitination
  • glycosylation
  • inflammatory pain
  • neuropathic pain
  • phosphorylation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Physiology (medical)

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