Technique of controlled reperfusion of the transplanted lung in humans

Scott D Lick, Paul S. Brown, Mark Kurusz, Roger A. Vertrees, Christopher K. McQuitty, William E. Johnston

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background. Reperfusion injury remains a significant and sometimes fatal problem in clinical lung transplantation. Controlled reperfusion of the transplanted lung using white cell-filtered, nutrient-enriched blood has been shown recently to significantly ameliorate reperfusion damage in a porcine model. We modified this experimental technique and applied it to human lung transplantation. Methods. Approximately 1,500 mL of arterial blood was slowly collected in a cardiotomy reservoir during the lung implant, and mixed to make a 4:1 solution of blood: modified Buckberg perfusate. This solution was passed through a leukocyte filter and into the transplant pulmonary artery for 10 minutes, at a controlled rate (200 mL/min) and pressure (less than 20 mm Hg), immediately before removal of the vascular clamp. Results. Five patients underwent lung transplantation (1 bilateral, 4 single lung) using this technique. All patients were ventilated on a 40% fraction of inspired oxygen within a few hours and extubated on or before the first postoperative day. Conclusions. Controlled reperfusion of the transplanted lung with white cell-filtered, nutrient-enriched blood has given excellent functional results in our small initial clinical series. (C) 2000 by The Society of Thoracic Surgeons.

Original languageEnglish (US)
Pages (from-to)910-912
Number of pages3
JournalAnnals of Thoracic Surgery
Volume69
Issue number3
DOIs
StatePublished - Mar 2000
Externally publishedYes

Fingerprint

Reperfusion
Lung Transplantation
Lung
Reperfusion Injury
Food
Pulmonary Artery
Blood Vessels
Leukocytes
Swine
Oxygen
Transplants
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Lick, S. D., Brown, P. S., Kurusz, M., Vertrees, R. A., McQuitty, C. K., & Johnston, W. E. (2000). Technique of controlled reperfusion of the transplanted lung in humans. Annals of Thoracic Surgery, 69(3), 910-912. https://doi.org/10.1016/S0003-4975(99)01436-8

Technique of controlled reperfusion of the transplanted lung in humans. / Lick, Scott D; Brown, Paul S.; Kurusz, Mark; Vertrees, Roger A.; McQuitty, Christopher K.; Johnston, William E.

In: Annals of Thoracic Surgery, Vol. 69, No. 3, 03.2000, p. 910-912.

Research output: Contribution to journalArticle

Lick, SD, Brown, PS, Kurusz, M, Vertrees, RA, McQuitty, CK & Johnston, WE 2000, 'Technique of controlled reperfusion of the transplanted lung in humans', Annals of Thoracic Surgery, vol. 69, no. 3, pp. 910-912. https://doi.org/10.1016/S0003-4975(99)01436-8
Lick, Scott D ; Brown, Paul S. ; Kurusz, Mark ; Vertrees, Roger A. ; McQuitty, Christopher K. ; Johnston, William E. / Technique of controlled reperfusion of the transplanted lung in humans. In: Annals of Thoracic Surgery. 2000 ; Vol. 69, No. 3. pp. 910-912.
@article{227603b74e594a33af4e87694a5428ae,
title = "Technique of controlled reperfusion of the transplanted lung in humans",
abstract = "Background. Reperfusion injury remains a significant and sometimes fatal problem in clinical lung transplantation. Controlled reperfusion of the transplanted lung using white cell-filtered, nutrient-enriched blood has been shown recently to significantly ameliorate reperfusion damage in a porcine model. We modified this experimental technique and applied it to human lung transplantation. Methods. Approximately 1,500 mL of arterial blood was slowly collected in a cardiotomy reservoir during the lung implant, and mixed to make a 4:1 solution of blood: modified Buckberg perfusate. This solution was passed through a leukocyte filter and into the transplant pulmonary artery for 10 minutes, at a controlled rate (200 mL/min) and pressure (less than 20 mm Hg), immediately before removal of the vascular clamp. Results. Five patients underwent lung transplantation (1 bilateral, 4 single lung) using this technique. All patients were ventilated on a 40{\%} fraction of inspired oxygen within a few hours and extubated on or before the first postoperative day. Conclusions. Controlled reperfusion of the transplanted lung with white cell-filtered, nutrient-enriched blood has given excellent functional results in our small initial clinical series. (C) 2000 by The Society of Thoracic Surgeons.",
author = "Lick, {Scott D} and Brown, {Paul S.} and Mark Kurusz and Vertrees, {Roger A.} and McQuitty, {Christopher K.} and Johnston, {William E.}",
year = "2000",
month = "3",
doi = "10.1016/S0003-4975(99)01436-8",
language = "English (US)",
volume = "69",
pages = "910--912",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Technique of controlled reperfusion of the transplanted lung in humans

AU - Lick, Scott D

AU - Brown, Paul S.

AU - Kurusz, Mark

AU - Vertrees, Roger A.

AU - McQuitty, Christopher K.

AU - Johnston, William E.

PY - 2000/3

Y1 - 2000/3

N2 - Background. Reperfusion injury remains a significant and sometimes fatal problem in clinical lung transplantation. Controlled reperfusion of the transplanted lung using white cell-filtered, nutrient-enriched blood has been shown recently to significantly ameliorate reperfusion damage in a porcine model. We modified this experimental technique and applied it to human lung transplantation. Methods. Approximately 1,500 mL of arterial blood was slowly collected in a cardiotomy reservoir during the lung implant, and mixed to make a 4:1 solution of blood: modified Buckberg perfusate. This solution was passed through a leukocyte filter and into the transplant pulmonary artery for 10 minutes, at a controlled rate (200 mL/min) and pressure (less than 20 mm Hg), immediately before removal of the vascular clamp. Results. Five patients underwent lung transplantation (1 bilateral, 4 single lung) using this technique. All patients were ventilated on a 40% fraction of inspired oxygen within a few hours and extubated on or before the first postoperative day. Conclusions. Controlled reperfusion of the transplanted lung with white cell-filtered, nutrient-enriched blood has given excellent functional results in our small initial clinical series. (C) 2000 by The Society of Thoracic Surgeons.

AB - Background. Reperfusion injury remains a significant and sometimes fatal problem in clinical lung transplantation. Controlled reperfusion of the transplanted lung using white cell-filtered, nutrient-enriched blood has been shown recently to significantly ameliorate reperfusion damage in a porcine model. We modified this experimental technique and applied it to human lung transplantation. Methods. Approximately 1,500 mL of arterial blood was slowly collected in a cardiotomy reservoir during the lung implant, and mixed to make a 4:1 solution of blood: modified Buckberg perfusate. This solution was passed through a leukocyte filter and into the transplant pulmonary artery for 10 minutes, at a controlled rate (200 mL/min) and pressure (less than 20 mm Hg), immediately before removal of the vascular clamp. Results. Five patients underwent lung transplantation (1 bilateral, 4 single lung) using this technique. All patients were ventilated on a 40% fraction of inspired oxygen within a few hours and extubated on or before the first postoperative day. Conclusions. Controlled reperfusion of the transplanted lung with white cell-filtered, nutrient-enriched blood has given excellent functional results in our small initial clinical series. (C) 2000 by The Society of Thoracic Surgeons.

UR - http://www.scopus.com/inward/record.url?scp=0034026262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034026262&partnerID=8YFLogxK

U2 - 10.1016/S0003-4975(99)01436-8

DO - 10.1016/S0003-4975(99)01436-8

M3 - Article

VL - 69

SP - 910

EP - 912

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 3

ER -