Technique of controlled reperfusion of the transplanted lung in humans

Scott D. Lick, Paul S. Brown, Mark Kurusz, Roger A. Vertrees, Christopher K. McQuitty, William E. Johnston

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Background. Reperfusion injury remains a significant and sometimes fatal problem in clinical lung transplantation. Controlled reperfusion of the transplanted lung using white cell-filtered, nutrient-enriched blood has been shown recently to significantly ameliorate reperfusion damage in a porcine model. We modified this experimental technique and applied it to human lung transplantation. Methods. Approximately 1,500 mL of arterial blood was slowly collected in a cardiotomy reservoir during the lung implant, and mixed to make a 4:1 solution of blood: modified Buckberg perfusate. This solution was passed through a leukocyte filter and into the transplant pulmonary artery for 10 minutes, at a controlled rate (200 mL/min) and pressure (less than 20 mm Hg), immediately before removal of the vascular clamp. Results. Five patients underwent lung transplantation (1 bilateral, 4 single lung) using this technique. All patients were ventilated on a 40% fraction of inspired oxygen within a few hours and extubated on or before the first postoperative day. Conclusions. Controlled reperfusion of the transplanted lung with white cell-filtered, nutrient-enriched blood has given excellent functional results in our small initial clinical series. (C) 2000 by The Society of Thoracic Surgeons.

Original languageEnglish (US)
Pages (from-to)910-912
Number of pages3
JournalAnnals of Thoracic Surgery
Volume69
Issue number3
DOIs
StatePublished - Mar 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Technique of controlled reperfusion of the transplanted lung in humans'. Together they form a unique fingerprint.

  • Cite this

    Lick, S. D., Brown, P. S., Kurusz, M., Vertrees, R. A., McQuitty, C. K., & Johnston, W. E. (2000). Technique of controlled reperfusion of the transplanted lung in humans. Annals of Thoracic Surgery, 69(3), 910-912. https://doi.org/10.1016/S0003-4975(99)01436-8