Tensins: A New Switch in Cell Migration

Ghassan Mouneimne, Joan S. Brugge

Research output: Contribution to journalShort survey

12 Scopus citations

Abstract

Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of β1 integrin with the actin cytoskeleton in focal adhesions.

Original languageEnglish (US)
Pages (from-to)317-319
Number of pages3
JournalDevelopmental Cell
Volume13
Issue number3
DOIs
StatePublished - Sep 4 2007
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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