Testing Synergistic Effects for Simultaneous Exposures with Stratified Dichotomous Response

Walter W. Piegorsch, Clarice R. Weinberg

Research output: Contribution to journalArticle

1 Scopus citations


This paper compares small sample performances of test statistics for assessing the degree of interaction between two exposures with respect to the occurrence of a time- stratified dichotomous outcome. Particular attention is focused towards cancer bioassays. A null model of simple, independent, joint action is adopted. Sizes and powers are examined via Monte Carlo simulations for the various statistics proposed under a variety of parameter configurations.

Original languageEnglish (US)
Pages (from-to)1-19
Number of pages19
JournalJournal of Statistical Computation and Simulation
Issue number1-2
StatePublished - Oct 1 1986
Externally publishedYes



  • Interaction
  • simple independent action
  • simulation

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Statistics, Probability and Uncertainty
  • Applied Mathematics

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