tetra-O-Methylnordihydroguaiaretic acid inhibits melanoma in vivo

Joshua D. Lambert, Ross O. Meyers, Barbara N. Timmermann, Robert T Dorr

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

tetra-O-Methylnordihydroguaiaretic acid is a derivative of a naturally-occurring lignan, nordihydroguaiaretic acid, that has previously been shown to inhibit various cancer types in vitro and in vivo. Additionally, nordihydroguaiaretic acid has been shown to have nephrotoxic effects in the rat. Here we show that tetra-O-methylnordihydroguaiaretic acid inhibits the growth of a number of tumor cell lines in vitro by inducing apoptosis in a non-schedule-dependent manner. Further, this compound inhibits the synthesis of DNA by melanoma cells and causes cell cycle arrest in G0/G1 and G2/M phases of the cell cycle. tetra-O-Methylnordihydroguaiaretic acid also inhibits the growth of both murine and human melanomas and human colon cancer in vivo without apparent hepatic or renal toxicity.

Original languageEnglish (US)
Pages (from-to)47-56
Number of pages10
JournalCancer Letters
Volume171
Issue number1
DOIs
StatePublished - Aug 28 2001

Fingerprint

Masoprocol
Melanoma
Lignans
G2 Phase
Growth
Cell Cycle Checkpoints
Tumor Cell Line
Cell Division
Colonic Neoplasms
Cell Cycle
Apoptosis
Kidney
Liver
DNA
terameprocol
Neoplasms
In Vitro Techniques

Keywords

  • Colon cancer
  • Melanoma
  • Nordihydroguaiaretic acid
  • tetra-O-Methylnordihydroguaiaretic acid

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

tetra-O-Methylnordihydroguaiaretic acid inhibits melanoma in vivo. / Lambert, Joshua D.; Meyers, Ross O.; Timmermann, Barbara N.; Dorr, Robert T.

In: Cancer Letters, Vol. 171, No. 1, 28.08.2001, p. 47-56.

Research output: Contribution to journalArticle

Lambert, Joshua D. ; Meyers, Ross O. ; Timmermann, Barbara N. ; Dorr, Robert T. / tetra-O-Methylnordihydroguaiaretic acid inhibits melanoma in vivo. In: Cancer Letters. 2001 ; Vol. 171, No. 1. pp. 47-56.
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