Texture analysis of speckle in optical coherence tomography images of tissue phantoms

Kirk W. Gossage, Cynthia M. Smith, Elizabeth M. Kanter, Lida P. Hariri, Alice L. Stone, Jeffrey J Rodriguez, Stuart K. Williams, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Optical coherence tomography (OCT) is an imaging modality capable of acquiring cross-sectional images of tissue using back-reflected light. Conventional OCT images have a resolution of 10-15μm, and are thus best suited for visualizing tissue layers and structures. OCT images of collagen (with and without endothelial cells) have no resolvable features and may appear to simply show an exponential decrease in intensity with depth. However, examination of these images reveals that they display a characteristic repetitive structure due to speckle. The purpose of this study is to evaluate the application of statistical and spectral texture analysis techniques for differentiating living and non-living tissue phantoms containing various sizes and distributions of scatterers based on speckle content in OCT images. Statistically significant differences between texture parameters and excellent classification rates were obtained when comparing various endothelial cell concentrations ranging from 0 cells/ml to 25 million/ml. Statistically significant results and excellent classification rates were also obtained using various sizes of microspheres with concentrations ranging from 0 microspheres/ ml to 500 million microspheres/ml. This study has shown that texture analysis of OCT images may be capable of differentiating tissue phantoms containing various sizes and distributions of scatterers.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.E. Cohn, W.S. Grundfest, D.A. Benaron, T. Vo-Dinh
Pages140-150
Number of pages11
Volume5318
DOIs
StatePublished - 2004
EventProgress in Biomedical Optics and Imaging - Adavnced Biomedical and Clinical Diagnostic Systems II - San Jose, CA, United States
Duration: Jan 25 2004Jan 26 2004

Other

OtherProgress in Biomedical Optics and Imaging - Adavnced Biomedical and Clinical Diagnostic Systems II
CountryUnited States
CitySan Jose, CA
Period1/25/041/26/04

Fingerprint

Optical tomography
Speckle
textures
Textures
tomography
Tissue
Microspheres
Endothelial cells
Collagen
collagens
scattering
Imaging techniques
examination
cells

Keywords

  • Collagen
  • Image Processing
  • Speckle
  • Texture Analysis
  • Tissue Phantoms

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Gossage, K. W., Smith, C. M., Kanter, E. M., Hariri, L. P., Stone, A. L., Rodriguez, J. J., ... Barton, J. K. (2004). Texture analysis of speckle in optical coherence tomography images of tissue phantoms. In G. E. Cohn, W. S. Grundfest, D. A. Benaron, & T. Vo-Dinh (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5318, pp. 140-150) https://doi.org/10.1117/12.529615

Texture analysis of speckle in optical coherence tomography images of tissue phantoms. / Gossage, Kirk W.; Smith, Cynthia M.; Kanter, Elizabeth M.; Hariri, Lida P.; Stone, Alice L.; Rodriguez, Jeffrey J; Williams, Stuart K.; Barton, Jennifer K.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.E. Cohn; W.S. Grundfest; D.A. Benaron; T. Vo-Dinh. Vol. 5318 2004. p. 140-150.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gossage, KW, Smith, CM, Kanter, EM, Hariri, LP, Stone, AL, Rodriguez, JJ, Williams, SK & Barton, JK 2004, Texture analysis of speckle in optical coherence tomography images of tissue phantoms. in GE Cohn, WS Grundfest, DA Benaron & T Vo-Dinh (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5318, pp. 140-150, Progress in Biomedical Optics and Imaging - Adavnced Biomedical and Clinical Diagnostic Systems II, San Jose, CA, United States, 1/25/04. https://doi.org/10.1117/12.529615
Gossage KW, Smith CM, Kanter EM, Hariri LP, Stone AL, Rodriguez JJ et al. Texture analysis of speckle in optical coherence tomography images of tissue phantoms. In Cohn GE, Grundfest WS, Benaron DA, Vo-Dinh T, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5318. 2004. p. 140-150 https://doi.org/10.1117/12.529615
Gossage, Kirk W. ; Smith, Cynthia M. ; Kanter, Elizabeth M. ; Hariri, Lida P. ; Stone, Alice L. ; Rodriguez, Jeffrey J ; Williams, Stuart K. ; Barton, Jennifer K. / Texture analysis of speckle in optical coherence tomography images of tissue phantoms. Proceedings of SPIE - The International Society for Optical Engineering. editor / G.E. Cohn ; W.S. Grundfest ; D.A. Benaron ; T. Vo-Dinh. Vol. 5318 2004. pp. 140-150
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