TGFβ1 and Treg cells: alliance for tolerance

Ramireddy Bommireddy, Thomas Doetschman

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

Transforming growth factor β1 (TGFβ1), an important pleiotropic, immunoregulatory cytokine, uses distinct signaling mechanisms in lymphocytes to affect T-cell homeostasis, regulatory T (Treg)-cell and effector-cell function and tumorigenesis. Defects in TGFβ1 expression or its signaling in T cells correlate with the onset of several autoimmune diseases. TGFβ1 prevents abnormal T-cell activation through the modulation of Ca2+-calcineurin signaling in a Caenorhabditis elegans Sma and Drosophila Mad proteins (SMAD)3 and SMAD4-independent manner; however, in Treg cells, its effects are mediated, at least in part, through SMAD signaling. TGFβ1 also acts as a pro-inflammatory cytokine and induces interleukin (IL)-17-producing pathogenic T-helper cells (Th IL-17 cells) synergistically during an inflammatory response in which IL-6 is produced. Here, we will review TGFβ1 and its signaling in T cells with an emphasis on the regulatory arm of immune tolerance.

Original languageEnglish (US)
Pages (from-to)492-501
Number of pages10
JournalTrends in Molecular Medicine
Volume13
Issue number11
DOIs
StatePublished - Nov 1 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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