TGFβ1 and Treg cells: alliance for tolerance

Ramireddy Bommireddy, Thomas C Doetschman

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Transforming growth factor β1 (TGFβ1), an important pleiotropic, immunoregulatory cytokine, uses distinct signaling mechanisms in lymphocytes to affect T-cell homeostasis, regulatory T (Treg)-cell and effector-cell function and tumorigenesis. Defects in TGFβ1 expression or its signaling in T cells correlate with the onset of several autoimmune diseases. TGFβ1 prevents abnormal T-cell activation through the modulation of Ca2+-calcineurin signaling in a Caenorhabditis elegans Sma and Drosophila Mad proteins (SMAD)3 and SMAD4-independent manner; however, in Treg cells, its effects are mediated, at least in part, through SMAD signaling. TGFβ1 also acts as a pro-inflammatory cytokine and induces interleukin (IL)-17-producing pathogenic T-helper cells (Th IL-17 cells) synergistically during an inflammatory response in which IL-6 is produced. Here, we will review TGFβ1 and its signaling in T cells with an emphasis on the regulatory arm of immune tolerance.

Original languageEnglish (US)
Pages (from-to)492-501
Number of pages10
JournalTrends in Molecular Medicine
Volume13
Issue number11
DOIs
StatePublished - Nov 2007

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Transforming Growth Factors
Regulatory T-Lymphocytes
T-Lymphocytes
Interleukin-17
Cytokines
Immune Tolerance
Calcineurin
Caenorhabditis elegans
Helper-Inducer T-Lymphocytes
Autoimmune Diseases
Interleukin-6
Carcinogenesis
Homeostasis
Lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

TGFβ1 and Treg cells : alliance for tolerance. / Bommireddy, Ramireddy; Doetschman, Thomas C.

In: Trends in Molecular Medicine, Vol. 13, No. 11, 11.2007, p. 492-501.

Research output: Contribution to journalArticle

Bommireddy, Ramireddy ; Doetschman, Thomas C. / TGFβ1 and Treg cells : alliance for tolerance. In: Trends in Molecular Medicine. 2007 ; Vol. 13, No. 11. pp. 492-501.
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