TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

L. Philip Sanford, Ilona Ormsby, Adriana C. Gittenberger-de Groot, Hannu Sariola, Rick Friedman, Gregory P. Boivin, Emma Lou Cardell, Thomas Doetschman

Research output: Contribution to journalArticlepeer-review

1087 Scopus citations

Abstract

The growth and differentiation factor transforming growth factor-β2 (TGFβ2) is thought to play important roles in multiple developmental processes. Targeted disruption of the TGFβ2 gene was undertaken to determine its essential role in vivo. TGFβ2-null mice exhibit perinatal mortality and a wide range of developmental defects for a single gene disruption. These include cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital defects. The developmental processes most commonly involved in the affected tissues include epithelial-mesenchymal interactions, cell growth, extracellular matrix production and tissue remodeling. In addition, many affected tissues have neural crest-derived components and simulate neural crest deficiencies. There is no phenotypic overlap with TGFβ1- and TGFβ3-null mice indicating numerous non-compensated functions between the TGFβ isoforms.

Original languageEnglish (US)
Pages (from-to)2659-2670
Number of pages12
JournalDevelopment
Volume124
Issue number13
StatePublished - Jul 1997

Keywords

  • Epithelial-mesenchymal interaction
  • Gene targeting
  • Heart defect
  • Knockout
  • Mouse
  • Skeletal defect
  • TGFβ2

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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