The actin-related protein2/3 complex regulates mitochondrial-associated calcium signaling during salt stress in Arabidopsis

Yi Zhao, Zhen Pan, Yan Zhang, Xiaolu Qu, Yuguo Zhang, Yongqing Yang, Xiangning Jiang, Shanjin Huang, Ming Yuan, Karen S. Schumaker, Yan Guo

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Microfilament and Ca2+ dynamics play important roles in stress signaling in plants. Through genetic screening of Arabidopsis thaliana mutants that are defective in stress-induced increases in cytosolic Ca2+ ([Ca2+]cyt), we identified Actin-Related Protein2 (Arp2) as a regulator of [Ca2+]cyt in response to salt stress. Plants lacking Arp2 or other proteins in the Arp2/3 complex exhibited enhanced salt-induced increases in [Ca2+]cyt, decreased mitochondria movement, and hypersensitivity to salt. In addition, mitochondria aggregated, the mitochondrial permeability transition pore opened, and mitochondrial membrane potential Wm was impaired in the arp2 mutant, and these changes were associated with salt-induced cell death. When opening of the enhanced mitochondrial permeability transition pore was blocked or increases in [Ca2+]cyt were prevented, the salt-sensitive phenotype of the arp2 mutant was partially rescued. These results indicate that the Arp2/3 complex regulates mitochondrial-dependent Ca2+ signaling in response to salt stress.

Original languageEnglish (US)
Pages (from-to)4544-4559
Number of pages16
JournalPlant Cell
Volume25
Issue number11
DOIs
StatePublished - Nov 2013

ASJC Scopus subject areas

  • Plant Science
  • Cell Biology

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