The actions of melanin-concentrating hormone (MCH) on passive avoidance in rats: A preliminary study

Rosanne B. McBride, Bill E. Beckwith, Robyn R. Swenson, Tomi K. Sawyer, Mac E. Hadley, Terry O. Matsunaga, Victor J. Hruby

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Melanin-concentrating hormone (MCH) is a hepadecapeptide hormone that is synthesized in the CNS and is responsible for melanosome aggregation in the teleost fish. Recent evidence suggests that this peptide hormone has a unique distribution in the mammalian brain, which leads to the speculation that it may serve as a neuromodulator. The present study was undertaken to explore the comparative effects of MCH to those of α-melanocyte-stimulating Hormone (MSH) (a neuropeptide that is known to influence learning) on the rate of extinction of a passive avoidance response in rats. Both MCH and MSH were administered SC at 10 μg per animal. Treatment with MCH appeared to hasten, whereas treatment with MSH appeared to delay, extinction of the passive avoidance response.

Original languageEnglish (US)
Pages (from-to)757-759
Number of pages3
JournalPeptides
Volume15
Issue number4
DOIs
StatePublished - 1994

Keywords

  • Behavior
  • Extinction
  • Learning
  • MCH
  • MSH
  • Memory
  • Neuropeptides
  • Passive avoidance

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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