The adherence of Candida yeasts to human and bovine vascular endothelium and subendothelial extracellular matrix

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The adherence of Candida albicans yeasts and other Candida species to human umbilical vein endothelial cells (HUVEC), bovine aortic endothelial cells (BAEC) and their respective subendothelial extracellular matrices (ECM) was studied. Yeast adherence to confluent HUVEC and BAEC appeared to occur at intercellular junctions and edges of endothelial cells in preference to the contoured surface of the endothelial cell. Both endothelial cell lines characteristically resisted yeast adherence. The resistance of endothelium to yeast adherence was especially pronounced in the presence of serum. On the other hand, there was avid yeast binding to the subendothelial ECMs, on the order of 200-500% greater than to monolayers of syngeneic endothelial cells.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalFEMS Microbiology Letters
Volume48
Issue number1-2
StatePublished - Dec 1 1987
Externally publishedYes

Fingerprint

Vascular Endothelium
Candida
Extracellular Matrix
Endothelial Cells
Yeasts
Human Umbilical Vein Endothelial Cells
Intercellular Junctions
Candida albicans
Endothelium
Cell Line
Serum

Keywords

  • Adherence
  • Candida sp.
  • Endothelium
  • Extracellular matrix

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

The adherence of Candida yeasts to human and bovine vascular endothelium and subendothelial extracellular matrix. / Klotz, Stephen A.

In: FEMS Microbiology Letters, Vol. 48, No. 1-2, 01.12.1987, p. 201-205.

Research output: Contribution to journalArticle

@article{4fe53adc983f42ffb0e765b7f4b0cb22,
title = "The adherence of Candida yeasts to human and bovine vascular endothelium and subendothelial extracellular matrix",
abstract = "The adherence of Candida albicans yeasts and other Candida species to human umbilical vein endothelial cells (HUVEC), bovine aortic endothelial cells (BAEC) and their respective subendothelial extracellular matrices (ECM) was studied. Yeast adherence to confluent HUVEC and BAEC appeared to occur at intercellular junctions and edges of endothelial cells in preference to the contoured surface of the endothelial cell. Both endothelial cell lines characteristically resisted yeast adherence. The resistance of endothelium to yeast adherence was especially pronounced in the presence of serum. On the other hand, there was avid yeast binding to the subendothelial ECMs, on the order of 200-500{\%} greater than to monolayers of syngeneic endothelial cells.",
keywords = "Adherence, Candida sp., Endothelium, Extracellular matrix",
author = "Klotz, {Stephen A}",
year = "1987",
month = "12",
day = "1",
language = "English (US)",
volume = "48",
pages = "201--205",
journal = "FEMS Microbiology Letters",
issn = "0378-1097",
publisher = "Wiley-Blackwell",
number = "1-2",

}

TY - JOUR

T1 - The adherence of Candida yeasts to human and bovine vascular endothelium and subendothelial extracellular matrix

AU - Klotz, Stephen A

PY - 1987/12/1

Y1 - 1987/12/1

N2 - The adherence of Candida albicans yeasts and other Candida species to human umbilical vein endothelial cells (HUVEC), bovine aortic endothelial cells (BAEC) and their respective subendothelial extracellular matrices (ECM) was studied. Yeast adherence to confluent HUVEC and BAEC appeared to occur at intercellular junctions and edges of endothelial cells in preference to the contoured surface of the endothelial cell. Both endothelial cell lines characteristically resisted yeast adherence. The resistance of endothelium to yeast adherence was especially pronounced in the presence of serum. On the other hand, there was avid yeast binding to the subendothelial ECMs, on the order of 200-500% greater than to monolayers of syngeneic endothelial cells.

AB - The adherence of Candida albicans yeasts and other Candida species to human umbilical vein endothelial cells (HUVEC), bovine aortic endothelial cells (BAEC) and their respective subendothelial extracellular matrices (ECM) was studied. Yeast adherence to confluent HUVEC and BAEC appeared to occur at intercellular junctions and edges of endothelial cells in preference to the contoured surface of the endothelial cell. Both endothelial cell lines characteristically resisted yeast adherence. The resistance of endothelium to yeast adherence was especially pronounced in the presence of serum. On the other hand, there was avid yeast binding to the subendothelial ECMs, on the order of 200-500% greater than to monolayers of syngeneic endothelial cells.

KW - Adherence

KW - Candida sp.

KW - Endothelium

KW - Extracellular matrix

UR - http://www.scopus.com/inward/record.url?scp=0023632182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023632182&partnerID=8YFLogxK

M3 - Article

VL - 48

SP - 201

EP - 205

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

SN - 0378-1097

IS - 1-2

ER -