The adherence of Pseudomonas aeruginosa to soft contact lenses

S. I. Butrus, Stephen A Klotz, R. P. Misra

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The adherence of Pseudomonas aeruginosa to extended-wear soft contact lenses (EWSCLs) may be an important initial step in the pathogenesis of EWSCL-associated infectious keratitis. P. aeruginosa tend to adhere more to worn EWSCLs than unworn EWSCLs (P < 0.05). Normal tear components such as aqueous solutions of albumin, lysozyme, and lactoferrin all significantly enhance adherence of P. aeruginosa to unworn EWSCLs often by as much as 300%. The presence of a 1% solution of sialic acid in the bathing medium significantly reduces the adherence of P. aeruginosa to both unworn and worn lenses. Inhibition of bacterial adherence could also be achieved with the addition of mucin (which contains terminal sialic acid residues in its major sugar chains). Therefore, selective adherence by P. aeruginosa to a specific sugar (sialic acid) may be important in the initial attachment of the bacterium to soft contact lenses.

Original languageEnglish (US)
Pages (from-to)1310-1314
Number of pages5
JournalOphthalmology
Volume94
Issue number10
StatePublished - 1987
Externally publishedYes

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Hydrophilic Contact Lens
Extended-Wear Contact Lenses
Pseudomonas aeruginosa
N-Acetylneuraminic Acid
Lactoferrin
Keratitis
Mucins
Muramidase
Tears
Lenses
Albumins
Bacteria

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Butrus, S. I., Klotz, S. A., & Misra, R. P. (1987). The adherence of Pseudomonas aeruginosa to soft contact lenses. Ophthalmology, 94(10), 1310-1314.

The adherence of Pseudomonas aeruginosa to soft contact lenses. / Butrus, S. I.; Klotz, Stephen A; Misra, R. P.

In: Ophthalmology, Vol. 94, No. 10, 1987, p. 1310-1314.

Research output: Contribution to journalArticle

Butrus, SI, Klotz, SA & Misra, RP 1987, 'The adherence of Pseudomonas aeruginosa to soft contact lenses', Ophthalmology, vol. 94, no. 10, pp. 1310-1314.
Butrus, S. I. ; Klotz, Stephen A ; Misra, R. P. / The adherence of Pseudomonas aeruginosa to soft contact lenses. In: Ophthalmology. 1987 ; Vol. 94, No. 10. pp. 1310-1314.
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