Abstract
This chapter reviews alterations observed in the hippocampus during normative ageing in the absence of pathology. Topics include discussions of age-related spatial memory deficits across mammalian species, as well as neuroanatomical, biophysical, and electrophysiological changes observed in the aged hippocampus. Further, the impact that these changes might have on plasticity mechanisms and dynamic processes such as gene expression and epigenetic modifications over the lifespan is discussed. Special emphasis is given to the fact that normative ageing is distinct from neuropathological states such as Alzheimer's disease. Moreover, this overview highlights how the study of normal ageing in the hippocampus has furthered the understanding of the specificity of pathological processes as well as presented possible avenues for the development of interventions, treatments, or therapeutic strategies for optimizing cognition during the normal life course.
| Original language | English (US) |
|---|---|
| Title of host publication | The Clinical Neurobiology of the Hippocampus: An Integrative view |
| Publisher | Oxford University Press |
| ISBN (Print) | 9780199949922, 9780199592388 |
| DOIs | |
| State | Published - Sep 20 2012 |
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Keywords
- DNA methylation
- Electrophysiology
- Immediate-early genes
- Multiple single-unit recording
- Neuroanatomical changes
- Place cells
- Plasticity
- Spatial memory
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
The Ageing Hippocampus. / Hoang, Lan T.; Lister, James P.; Barnes, Carol A.
The Clinical Neurobiology of the Hippocampus: An Integrative view. Oxford University Press, 2012.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The Ageing Hippocampus
AU - Hoang, Lan T.
AU - Lister, James P.
AU - Barnes, Carol A
PY - 2012/9/20
Y1 - 2012/9/20
N2 - This chapter reviews alterations observed in the hippocampus during normative ageing in the absence of pathology. Topics include discussions of age-related spatial memory deficits across mammalian species, as well as neuroanatomical, biophysical, and electrophysiological changes observed in the aged hippocampus. Further, the impact that these changes might have on plasticity mechanisms and dynamic processes such as gene expression and epigenetic modifications over the lifespan is discussed. Special emphasis is given to the fact that normative ageing is distinct from neuropathological states such as Alzheimer's disease. Moreover, this overview highlights how the study of normal ageing in the hippocampus has furthered the understanding of the specificity of pathological processes as well as presented possible avenues for the development of interventions, treatments, or therapeutic strategies for optimizing cognition during the normal life course.
AB - This chapter reviews alterations observed in the hippocampus during normative ageing in the absence of pathology. Topics include discussions of age-related spatial memory deficits across mammalian species, as well as neuroanatomical, biophysical, and electrophysiological changes observed in the aged hippocampus. Further, the impact that these changes might have on plasticity mechanisms and dynamic processes such as gene expression and epigenetic modifications over the lifespan is discussed. Special emphasis is given to the fact that normative ageing is distinct from neuropathological states such as Alzheimer's disease. Moreover, this overview highlights how the study of normal ageing in the hippocampus has furthered the understanding of the specificity of pathological processes as well as presented possible avenues for the development of interventions, treatments, or therapeutic strategies for optimizing cognition during the normal life course.
KW - DNA methylation
KW - Electrophysiology
KW - Immediate-early genes
KW - Multiple single-unit recording
KW - Neuroanatomical changes
KW - Place cells
KW - Plasticity
KW - Spatial memory
UR - http://www.scopus.com/inward/record.url?scp=84920425355&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920425355&partnerID=8YFLogxK
U2 - 10.1093/acprof:oso/9780199592388.003.0009
DO - 10.1093/acprof:oso/9780199592388.003.0009
M3 - Chapter
AN - SCOPUS:84920425355
SN - 9780199949922
SN - 9780199592388
BT - The Clinical Neurobiology of the Hippocampus: An Integrative view
PB - Oxford University Press
ER -