The Ageing Hippocampus

Lan T. Hoang, James P. Lister, Carol A Barnes

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

This chapter reviews alterations observed in the hippocampus during normative ageing in the absence of pathology. Topics include discussions of age-related spatial memory deficits across mammalian species, as well as neuroanatomical, biophysical, and electrophysiological changes observed in the aged hippocampus. Further, the impact that these changes might have on plasticity mechanisms and dynamic processes such as gene expression and epigenetic modifications over the lifespan is discussed. Special emphasis is given to the fact that normative ageing is distinct from neuropathological states such as Alzheimer's disease. Moreover, this overview highlights how the study of normal ageing in the hippocampus has furthered the understanding of the specificity of pathological processes as well as presented possible avenues for the development of interventions, treatments, or therapeutic strategies for optimizing cognition during the normal life course.

Original languageEnglish (US)
Title of host publicationThe Clinical Neurobiology of the Hippocampus: An Integrative view
PublisherOxford University Press
ISBN (Print)9780199949922, 9780199592388
DOIs
StatePublished - Sep 20 2012

Fingerprint

Hippocampus
Memory Disorders
Pathologic Processes
Epigenomics
Cognition
Alzheimer Disease
Pathology
Gene Expression
Therapeutics
Spatial Memory

Keywords

  • DNA methylation
  • Electrophysiology
  • Immediate-early genes
  • Multiple single-unit recording
  • Neuroanatomical changes
  • Place cells
  • Plasticity
  • Spatial memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hoang, L. T., Lister, J. P., & Barnes, C. A. (2012). The Ageing Hippocampus. In The Clinical Neurobiology of the Hippocampus: An Integrative view Oxford University Press. https://doi.org/10.1093/acprof:oso/9780199592388.003.0009

The Ageing Hippocampus. / Hoang, Lan T.; Lister, James P.; Barnes, Carol A.

The Clinical Neurobiology of the Hippocampus: An Integrative view. Oxford University Press, 2012.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hoang, LT, Lister, JP & Barnes, CA 2012, The Ageing Hippocampus. in The Clinical Neurobiology of the Hippocampus: An Integrative view. Oxford University Press. https://doi.org/10.1093/acprof:oso/9780199592388.003.0009
Hoang LT, Lister JP, Barnes CA. The Ageing Hippocampus. In The Clinical Neurobiology of the Hippocampus: An Integrative view. Oxford University Press. 2012 https://doi.org/10.1093/acprof:oso/9780199592388.003.0009
Hoang, Lan T. ; Lister, James P. ; Barnes, Carol A. / The Ageing Hippocampus. The Clinical Neurobiology of the Hippocampus: An Integrative view. Oxford University Press, 2012.
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