The Aging Navigational System

Adam W. Lester, Scott D. Moffat, Jan M. Wiener, Carol A Barnes, Thomas Wolbers

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)1019-1035
Number of pages17
JournalNeuron
Volume95
Issue number5
DOIs
StatePublished - Aug 30 2017

Fingerprint

Learning
Behavioral Research
Information Storage and Retrieval
Human Body
Neuroimaging
Neurodegenerative Diseases
Primates
Rodentia
Brain
Spatial Navigation
Grid Cells
Cognitive Aging
Place Cells
Spatial Memory

Keywords

  • aging
  • Alzheimer's disease
  • cognitive map
  • dementia
  • entorhinal cortex
  • grid cells
  • hippocampus
  • memory
  • place cells
  • spatial navigation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lester, A. W., Moffat, S. D., Wiener, J. M., Barnes, C. A., & Wolbers, T. (2017). The Aging Navigational System. Neuron, 95(5), 1019-1035. https://doi.org/10.1016/j.neuron.2017.06.037

The Aging Navigational System. / Lester, Adam W.; Moffat, Scott D.; Wiener, Jan M.; Barnes, Carol A; Wolbers, Thomas.

In: Neuron, Vol. 95, No. 5, 30.08.2017, p. 1019-1035.

Research output: Contribution to journalReview article

Lester, AW, Moffat, SD, Wiener, JM, Barnes, CA & Wolbers, T 2017, 'The Aging Navigational System', Neuron, vol. 95, no. 5, pp. 1019-1035. https://doi.org/10.1016/j.neuron.2017.06.037
Lester AW, Moffat SD, Wiener JM, Barnes CA, Wolbers T. The Aging Navigational System. Neuron. 2017 Aug 30;95(5):1019-1035. https://doi.org/10.1016/j.neuron.2017.06.037
Lester, Adam W. ; Moffat, Scott D. ; Wiener, Jan M. ; Barnes, Carol A ; Wolbers, Thomas. / The Aging Navigational System. In: Neuron. 2017 ; Vol. 95, No. 5. pp. 1019-1035.
@article{9672696e3af5454fa8564dfc8a52ebe3,
title = "The Aging Navigational System",
abstract = "The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.",
keywords = "aging, Alzheimer's disease, cognitive map, dementia, entorhinal cortex, grid cells, hippocampus, memory, place cells, spatial navigation",
author = "Lester, {Adam W.} and Moffat, {Scott D.} and Wiener, {Jan M.} and Barnes, {Carol A} and Thomas Wolbers",
year = "2017",
month = "8",
day = "30",
doi = "10.1016/j.neuron.2017.06.037",
language = "English (US)",
volume = "95",
pages = "1019--1035",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - The Aging Navigational System

AU - Lester, Adam W.

AU - Moffat, Scott D.

AU - Wiener, Jan M.

AU - Barnes, Carol A

AU - Wolbers, Thomas

PY - 2017/8/30

Y1 - 2017/8/30

N2 - The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.

AB - The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.

KW - aging

KW - Alzheimer's disease

KW - cognitive map

KW - dementia

KW - entorhinal cortex

KW - grid cells

KW - hippocampus

KW - memory

KW - place cells

KW - spatial navigation

UR - http://www.scopus.com/inward/record.url?scp=85028599998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028599998&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2017.06.037

DO - 10.1016/j.neuron.2017.06.037

M3 - Review article

C2 - 28858613

AN - SCOPUS:85028599998

VL - 95

SP - 1019

EP - 1035

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 5

ER -