The application of nanomaterials in controlled drug delivery for bone regeneration

Shuo Shi, Wenbao Jiang, Tianxiao Zhao, Katerina E. Aifantis, Hui Wang, Lei Lin, Yubo Fan, Qingling Feng, Fu Zhai Cui, Xiaoming Li

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Bone regeneration is a complicated process that involves a series of biological events, such as cellular recruitment, proliferation and differentiation, and so forth, which have been found to be significantly affected by controlled drug delivery. Recently, a lot of research studies have been launched on the application of nanomaterials in controlled drug delivery for bone regeneration. In this article, the latest research progress in this area regarding the use of bioceramics-based, polymer-based, metallic oxide-based and other types of nanomaterials in controlled drug delivery for bone regeneration are reviewed and discussed, which indicates that the controlling drug delivery with nanomaterials should be a very promising treatment in orthopedics. Furthermore, some new challenges about the future research on the application of nanomaterials in controlled drug delivery for bone regeneration are described in the conclusion and perspectives part.

Original languageEnglish (US)
Pages (from-to)3978-3992
Number of pages15
JournalJournal of Biomedical Materials Research - Part A
Volume103
Issue number12
DOIs
StatePublished - Dec 2015

Keywords

  • bone regeneration
  • controlled drug delivery
  • nanomaterials

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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