The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome

Fred S. Dietrich, Sylvia Voegeli, Sophie Brachat, Anita Lerch, Krista Gates, Sabine Steiner, Christine Mohr, Rainer Pöhlmann, Philippe Luedi, Sangdun Choi, Rod A. Wing, Albert Flavier, Thomas D. Gaffney, Peter Philippsen

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Abstract

We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalScience
Volume304
Issue number5668
DOIs
StatePublished - Apr 9 2004

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    Dietrich, F. S., Voegeli, S., Brachat, S., Lerch, A., Gates, K., Steiner, S., Mohr, C., Pöhlmann, R., Luedi, P., Choi, S., Wing, R. A., Flavier, A., Gaffney, T. D., & Philippsen, P. (2004). The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome. Science, 304(5668), 304-307. https://doi.org/10.1126/science.1095781