The association between obstructive sleep apnea and neurocognitive performance - The apnea positive pressure long-term efficacy study (APPLES)

Stuart F Quan, Cynthia S. Chan, William C. Dement, Alan Gevins, James L. Goodwin, Daniel J. Gottlieb, Sylvan Green, Christian Guilleminault, Max Hirshkowitz, Pamela R. Hyde, Gary G. Kay, Eileen B. Leary, Deborah A. Nichols, Paula K. Schweitzer, Richard D. Simon, James K. Walsh, Clete A. Kushida

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Study Objectives: To determine associations between obstructive sleep apnea (OSA) and neurocognitive performance in a large cohort of adults. Study Design: Cross-sectional analyses of polysomnographic and neurocognitive data from 1204 adult participants with a clinical diagnosis of obstructive sleep apnea (OSA) in the Apnea Positive Pressure Long-term Efficacy Study (APPLES), assessed at baseline before randomization to either continuous positive airway pressure (CPAP) or sham CPAP. Measurements: Sleep and respiratory indices obtained by laboratory polysomnography and several measures of neurocognitive performance. Results: Weak correlations were found for both the apnea hypopnea index (AHI) and several indices of oxygen desaturation and neurocognitive performance in unadjusted analyses. After adjustment for level of education, ethnicity, and gender, there was no association between the AHI and neurocognitive performance. However, severity of oxygen desaturation was weakly associated with worse neurocognitive performance on some measures of intelligence, attention, and processing speed. Conclusions: The impact of OSA on neurocognitive performance is small for many individuals with this condition and is most related to the severity of hypoxemia.

Original languageEnglish (US)
JournalSleep
Volume34
Issue number3
StatePublished - Mar 1 2011

Fingerprint

Obstructive Sleep Apnea
Apnea
Continuous Positive Airway Pressure
Pressure
Oxygen
Polysomnography
Random Allocation
Intelligence
Sleep
Cross-Sectional Studies
Education

Keywords

  • Epidemiology
  • Neurocognition
  • Obstructive sleep apnea
  • Oxygen desaturation
  • Sleep

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Quan, S. F., Chan, C. S., Dement, W. C., Gevins, A., Goodwin, J. L., Gottlieb, D. J., ... Kushida, C. A. (2011). The association between obstructive sleep apnea and neurocognitive performance - The apnea positive pressure long-term efficacy study (APPLES). Sleep, 34(3).

The association between obstructive sleep apnea and neurocognitive performance - The apnea positive pressure long-term efficacy study (APPLES). / Quan, Stuart F; Chan, Cynthia S.; Dement, William C.; Gevins, Alan; Goodwin, James L.; Gottlieb, Daniel J.; Green, Sylvan; Guilleminault, Christian; Hirshkowitz, Max; Hyde, Pamela R.; Kay, Gary G.; Leary, Eileen B.; Nichols, Deborah A.; Schweitzer, Paula K.; Simon, Richard D.; Walsh, James K.; Kushida, Clete A.

In: Sleep, Vol. 34, No. 3, 01.03.2011.

Research output: Contribution to journalArticle

Quan, SF, Chan, CS, Dement, WC, Gevins, A, Goodwin, JL, Gottlieb, DJ, Green, S, Guilleminault, C, Hirshkowitz, M, Hyde, PR, Kay, GG, Leary, EB, Nichols, DA, Schweitzer, PK, Simon, RD, Walsh, JK & Kushida, CA 2011, 'The association between obstructive sleep apnea and neurocognitive performance - The apnea positive pressure long-term efficacy study (APPLES)', Sleep, vol. 34, no. 3.
Quan, Stuart F ; Chan, Cynthia S. ; Dement, William C. ; Gevins, Alan ; Goodwin, James L. ; Gottlieb, Daniel J. ; Green, Sylvan ; Guilleminault, Christian ; Hirshkowitz, Max ; Hyde, Pamela R. ; Kay, Gary G. ; Leary, Eileen B. ; Nichols, Deborah A. ; Schweitzer, Paula K. ; Simon, Richard D. ; Walsh, James K. ; Kushida, Clete A. / The association between obstructive sleep apnea and neurocognitive performance - The apnea positive pressure long-term efficacy study (APPLES). In: Sleep. 2011 ; Vol. 34, No. 3.
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abstract = "Study Objectives: To determine associations between obstructive sleep apnea (OSA) and neurocognitive performance in a large cohort of adults. Study Design: Cross-sectional analyses of polysomnographic and neurocognitive data from 1204 adult participants with a clinical diagnosis of obstructive sleep apnea (OSA) in the Apnea Positive Pressure Long-term Efficacy Study (APPLES), assessed at baseline before randomization to either continuous positive airway pressure (CPAP) or sham CPAP. Measurements: Sleep and respiratory indices obtained by laboratory polysomnography and several measures of neurocognitive performance. Results: Weak correlations were found for both the apnea hypopnea index (AHI) and several indices of oxygen desaturation and neurocognitive performance in unadjusted analyses. After adjustment for level of education, ethnicity, and gender, there was no association between the AHI and neurocognitive performance. However, severity of oxygen desaturation was weakly associated with worse neurocognitive performance on some measures of intelligence, attention, and processing speed. Conclusions: The impact of OSA on neurocognitive performance is small for many individuals with this condition and is most related to the severity of hypoxemia.",
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