The autoradiographic distribution of kassinin and substance K binding sites is different from the distribution of substance P binding sites in rat brain

Patrick W. Mantyh, John E. Maggio, Stephen P. Hunt

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

In the present report we have used autoradiographic receptor binding technques to compare the distribution of substance K (SK), kassinin (K) and substance P (SP) binding sites in the rat brain. Whereas the distribution of K and SK binding sites appeared to be identical, notable differences are apparent when comparing these binding sites to the distribution of SP binding sites. These results demonstrate that in many areas of the rat brain K and SK binding sites have a different distribution than SP binding sites. These results further suggest that different classes of mammalian tachykinins may each have their own set of receptors.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalEuropean Journal of Pharmacology
Volume102
Issue number2
DOIs
StatePublished - Jul 13 1984
Externally publishedYes

Keywords

  • Autoradiography
  • Multiple receptors
  • Substance K
  • Substance P
  • Tachykinins

ASJC Scopus subject areas

  • Pharmacology

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