The benzodiazepine receptor of mammalian brain

R. C. Speth, R. W. Johnson, J. Regan, T. Reisine, R. M. Kobayashi, N. Bresolin, W. R. Roeske, H. I. Yamamura

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

There exists a saturable, high-affinity, stereospecific, regionally and pharmacologically specific, neuronally localized benzodiazepine receptor in mammalian brain, which has a development profile similar to other neurotransmitter receptors. This receptor appears to be modulated by γ-aminobutyric acid and selected divalent cations, and chloride ions increase the affinity of the receptor for benzodiazepines. Several benzodiazepines were shown to bind irreversibly to the receptor upon exposure to ultraviolet light and these agents can be used to facilitate solubilization and purification of the benzodiazepine receptor. Although several substances have been suggested to be the endogenous ligand, none has achieved the acceptance given to other neurotransmitters or neuromodulators, e.g., enkephalins and endorphins.

Original languageEnglish (US)
Pages (from-to)3032-3038
Number of pages7
JournalFederation Proceedings
Volume39
Issue number12
StatePublished - 1980

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GABA-A Receptors
Neurotransmitter Agents
Brain
Endorphins
Aminobutyrates
Neurotransmitter Receptor
Enkephalins
Divalent Cations
Ultraviolet Rays
Benzodiazepines
Chlorides
Ions
Ligands

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Speth, R. C., Johnson, R. W., Regan, J., Reisine, T., Kobayashi, R. M., Bresolin, N., ... Yamamura, H. I. (1980). The benzodiazepine receptor of mammalian brain. Federation Proceedings, 39(12), 3032-3038.

The benzodiazepine receptor of mammalian brain. / Speth, R. C.; Johnson, R. W.; Regan, J.; Reisine, T.; Kobayashi, R. M.; Bresolin, N.; Roeske, W. R.; Yamamura, H. I.

In: Federation Proceedings, Vol. 39, No. 12, 1980, p. 3032-3038.

Research output: Contribution to journalArticle

Speth, RC, Johnson, RW, Regan, J, Reisine, T, Kobayashi, RM, Bresolin, N, Roeske, WR & Yamamura, HI 1980, 'The benzodiazepine receptor of mammalian brain', Federation Proceedings, vol. 39, no. 12, pp. 3032-3038.
Speth RC, Johnson RW, Regan J, Reisine T, Kobayashi RM, Bresolin N et al. The benzodiazepine receptor of mammalian brain. Federation Proceedings. 1980;39(12):3032-3038.
Speth, R. C. ; Johnson, R. W. ; Regan, J. ; Reisine, T. ; Kobayashi, R. M. ; Bresolin, N. ; Roeske, W. R. ; Yamamura, H. I. / The benzodiazepine receptor of mammalian brain. In: Federation Proceedings. 1980 ; Vol. 39, No. 12. pp. 3032-3038.
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