The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips

Cong Zhao, Rui Xu, Kui Song, Dayu Liu, Shuo Ma, Chen Tang, Chun Liang, Yitshak Zohar, Yi Kuen Lee

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations

Abstract

We present a systematic study of the Capillary number (Ca) effect on the capture efficiency of cancer cells on a composite microfluidic filtration chip. By altering the Ca in microchip experiments, the balance between the viscous force and the cell cortical tension affecting the capture efficiency has been investigated experimentally and analyzed theoretically. A 'Phase Diagram' for the capture efficiency of microfiltration chips is presented, for the first time, as a function of the normalized cell diameter and Ca. A critical value of Ca, around 0.03∼0.04, has been identified for enhancing the capture efficiency of cancer cells. The phase diagram is found to be consistent with the results of cancer-cell capture in microfiltration systems reported previously by others. The diagram can be a useful tool for designing the next generation microfiltration devices for isolating circulating tumor cells.

Original languageEnglish (US)
Article number7050989
Pages (from-to)459-462
Number of pages4
JournalProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2015-February
Issue numberFebruary
DOIs
StatePublished - Feb 26 2015
Event2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015 - Estoril, Portugal
Duration: Jan 18 2015Jan 22 2015

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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