The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips

Cong Zhao, Rui Xu, Kui Song, Dayu Liu, Shuo Ma, Chen Tang, Chun Liang, Yitshak Zohar, Yi Kuen Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We present a systematic study of the Capillary number (Ca) effect on the capture efficiency of cancer cells on a composite microfluidic filtration chip. By altering the Ca in microchip experiments, the balance between the viscous force and the cell cortical tension affecting the capture efficiency has been investigated experimentally and analyzed theoretically. A 'Phase Diagram' for the capture efficiency of microfiltration chips is presented, for the first time, as a function of the normalized cell diameter and Ca. A critical value of Ca, around 0.03∼0.04, has been identified for enhancing the capture efficiency of cancer cells. The phase diagram is found to be consistent with the results of cancer-cell capture in microfiltration systems reported previously by others. The diagram can be a useful tool for designing the next generation microfiltration devices for isolating circulating tumor cells.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages459-462
Number of pages4
Volume2015-February
EditionFebruary
DOIs
StatePublished - Feb 26 2015
Event2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015 - Estoril, Portugal
Duration: Jan 18 2015Jan 22 2015

Other

Other2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015
CountryPortugal
CityEstoril
Period1/18/151/22/15

Fingerprint

Microfluidics
Microfiltration
cancer
chips
Cells
composite materials
Composite materials
Phase diagrams
cells
phase diagrams
Tumors
tumors
diagrams
Experiments

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Zhao, C., Xu, R., Song, K., Liu, D., Ma, S., Tang, C., ... Lee, Y. K. (2015). The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (February ed., Vol. 2015-February, pp. 459-462). [7050989] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2015.7050989

The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips. / Zhao, Cong; Xu, Rui; Song, Kui; Liu, Dayu; Ma, Shuo; Tang, Chen; Liang, Chun; Zohar, Yitshak; Lee, Yi Kuen.

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). Vol. 2015-February February. ed. Institute of Electrical and Electronics Engineers Inc., 2015. p. 459-462 7050989.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhao, C, Xu, R, Song, K, Liu, D, Ma, S, Tang, C, Liang, C, Zohar, Y & Lee, YK 2015, The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips. in Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). February edn, vol. 2015-February, 7050989, Institute of Electrical and Electronics Engineers Inc., pp. 459-462, 2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015, Estoril, Portugal, 1/18/15. https://doi.org/10.1109/MEMSYS.2015.7050989
Zhao C, Xu R, Song K, Liu D, Ma S, Tang C et al. The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). February ed. Vol. 2015-February. Institute of Electrical and Electronics Engineers Inc. 2015. p. 459-462. 7050989 https://doi.org/10.1109/MEMSYS.2015.7050989
Zhao, Cong ; Xu, Rui ; Song, Kui ; Liu, Dayu ; Ma, Shuo ; Tang, Chen ; Liang, Chun ; Zohar, Yitshak ; Lee, Yi Kuen. / The Capillary number effect on the capture efficiency of cancer cells on composite microfluidic filtration chips. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). Vol. 2015-February February. ed. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 459-462
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