The chemical dynamics of NO and reactive nitrogen oxides: A practical guide

Daniele Mancardi, Lisa A. Ridnour, Douglas D. Thomas, Tatsuo Katori, Carlo G. Tocchetti, Michael G. Espey, Katrina M Miranda, Nazareno Paolocci, David A. Wink

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Nitric oxide has emerged as one of the most important and diverse players in physiology. This small diatomic radical stunned researchers because of its existence and unique biological properties in human physiology. Over the last two decades it was found that NO often has fickle behavior in pathophysiological mechanisms. Where benefiting the host in one case yet inducing and augmenting injury in another. This has lead to confusion in is NO good or bad? Much of the answers to this dichotomy lies in the chemistry of NO and its related nitrogen oxide species. To help understand the complex chemistry with perspective to biology, a discussion on the chemical biology of NO is useful. The chemical biology defines the relevant chemical reaction of NO and nitrogen monoxide in the context of the biological conditions. We discuss in this article the chemistry of nitrogen oxide with different types of biological motifs. Reaction of NO with metal complexes and radicals require low concentration, where formation of reactive nitrogen oxide species require considerably higher amounts and generally are isolated to specific microenvironments in vivo. Though many reactive nitrogen oxide species are formed from chemical reactions with NO, there are several which appear to not require NO to be present, HNO and NO2. These two species have unique physiological effects and represent additional complexity to this biological picture. From this discussion, a picture can be formed concerning the possible chemical dynamics, which can be plausible in different biological mechanisms.

Original languageEnglish (US)
Pages (from-to)723-740
Number of pages18
JournalCurrent Molecular Medicine
Volume4
Issue number7
DOIs
StatePublished - Nov 2004

Fingerprint

Nitrogen Oxides
Nitric Oxide
Reactive Nitrogen Species
Physiology
Chemical reactions
Confusion
Coordination Complexes
Research Personnel
Wounds and Injuries

ASJC Scopus subject areas

  • Biochemistry

Cite this

Mancardi, D., Ridnour, L. A., Thomas, D. D., Katori, T., Tocchetti, C. G., Espey, M. G., ... Wink, D. A. (2004). The chemical dynamics of NO and reactive nitrogen oxides: A practical guide. Current Molecular Medicine, 4(7), 723-740. https://doi.org/10.2174/1566524043359854

The chemical dynamics of NO and reactive nitrogen oxides : A practical guide. / Mancardi, Daniele; Ridnour, Lisa A.; Thomas, Douglas D.; Katori, Tatsuo; Tocchetti, Carlo G.; Espey, Michael G.; Miranda, Katrina M; Paolocci, Nazareno; Wink, David A.

In: Current Molecular Medicine, Vol. 4, No. 7, 11.2004, p. 723-740.

Research output: Contribution to journalArticle

Mancardi, D, Ridnour, LA, Thomas, DD, Katori, T, Tocchetti, CG, Espey, MG, Miranda, KM, Paolocci, N & Wink, DA 2004, 'The chemical dynamics of NO and reactive nitrogen oxides: A practical guide', Current Molecular Medicine, vol. 4, no. 7, pp. 723-740. https://doi.org/10.2174/1566524043359854
Mancardi D, Ridnour LA, Thomas DD, Katori T, Tocchetti CG, Espey MG et al. The chemical dynamics of NO and reactive nitrogen oxides: A practical guide. Current Molecular Medicine. 2004 Nov;4(7):723-740. https://doi.org/10.2174/1566524043359854
Mancardi, Daniele ; Ridnour, Lisa A. ; Thomas, Douglas D. ; Katori, Tatsuo ; Tocchetti, Carlo G. ; Espey, Michael G. ; Miranda, Katrina M ; Paolocci, Nazareno ; Wink, David A. / The chemical dynamics of NO and reactive nitrogen oxides : A practical guide. In: Current Molecular Medicine. 2004 ; Vol. 4, No. 7. pp. 723-740.
@article{069aeaed9abd4b30bd759fee9aa02f41,
title = "The chemical dynamics of NO and reactive nitrogen oxides: A practical guide",
abstract = "Nitric oxide has emerged as one of the most important and diverse players in physiology. This small diatomic radical stunned researchers because of its existence and unique biological properties in human physiology. Over the last two decades it was found that NO often has fickle behavior in pathophysiological mechanisms. Where benefiting the host in one case yet inducing and augmenting injury in another. This has lead to confusion in is NO good or bad? Much of the answers to this dichotomy lies in the chemistry of NO and its related nitrogen oxide species. To help understand the complex chemistry with perspective to biology, a discussion on the chemical biology of NO is useful. The chemical biology defines the relevant chemical reaction of NO and nitrogen monoxide in the context of the biological conditions. We discuss in this article the chemistry of nitrogen oxide with different types of biological motifs. Reaction of NO with metal complexes and radicals require low concentration, where formation of reactive nitrogen oxide species require considerably higher amounts and generally are isolated to specific microenvironments in vivo. Though many reactive nitrogen oxide species are formed from chemical reactions with NO, there are several which appear to not require NO to be present, HNO and NO2. These two species have unique physiological effects and represent additional complexity to this biological picture. From this discussion, a picture can be formed concerning the possible chemical dynamics, which can be plausible in different biological mechanisms.",
author = "Daniele Mancardi and Ridnour, {Lisa A.} and Thomas, {Douglas D.} and Tatsuo Katori and Tocchetti, {Carlo G.} and Espey, {Michael G.} and Miranda, {Katrina M} and Nazareno Paolocci and Wink, {David A.}",
year = "2004",
month = "11",
doi = "10.2174/1566524043359854",
language = "English (US)",
volume = "4",
pages = "723--740",
journal = "Current Molecular Medicine",
issn = "1566-5240",
publisher = "Bentham Science Publishers B.V.",
number = "7",

}

TY - JOUR

T1 - The chemical dynamics of NO and reactive nitrogen oxides

T2 - A practical guide

AU - Mancardi, Daniele

AU - Ridnour, Lisa A.

AU - Thomas, Douglas D.

AU - Katori, Tatsuo

AU - Tocchetti, Carlo G.

AU - Espey, Michael G.

AU - Miranda, Katrina M

AU - Paolocci, Nazareno

AU - Wink, David A.

PY - 2004/11

Y1 - 2004/11

N2 - Nitric oxide has emerged as one of the most important and diverse players in physiology. This small diatomic radical stunned researchers because of its existence and unique biological properties in human physiology. Over the last two decades it was found that NO often has fickle behavior in pathophysiological mechanisms. Where benefiting the host in one case yet inducing and augmenting injury in another. This has lead to confusion in is NO good or bad? Much of the answers to this dichotomy lies in the chemistry of NO and its related nitrogen oxide species. To help understand the complex chemistry with perspective to biology, a discussion on the chemical biology of NO is useful. The chemical biology defines the relevant chemical reaction of NO and nitrogen monoxide in the context of the biological conditions. We discuss in this article the chemistry of nitrogen oxide with different types of biological motifs. Reaction of NO with metal complexes and radicals require low concentration, where formation of reactive nitrogen oxide species require considerably higher amounts and generally are isolated to specific microenvironments in vivo. Though many reactive nitrogen oxide species are formed from chemical reactions with NO, there are several which appear to not require NO to be present, HNO and NO2. These two species have unique physiological effects and represent additional complexity to this biological picture. From this discussion, a picture can be formed concerning the possible chemical dynamics, which can be plausible in different biological mechanisms.

AB - Nitric oxide has emerged as one of the most important and diverse players in physiology. This small diatomic radical stunned researchers because of its existence and unique biological properties in human physiology. Over the last two decades it was found that NO often has fickle behavior in pathophysiological mechanisms. Where benefiting the host in one case yet inducing and augmenting injury in another. This has lead to confusion in is NO good or bad? Much of the answers to this dichotomy lies in the chemistry of NO and its related nitrogen oxide species. To help understand the complex chemistry with perspective to biology, a discussion on the chemical biology of NO is useful. The chemical biology defines the relevant chemical reaction of NO and nitrogen monoxide in the context of the biological conditions. We discuss in this article the chemistry of nitrogen oxide with different types of biological motifs. Reaction of NO with metal complexes and radicals require low concentration, where formation of reactive nitrogen oxide species require considerably higher amounts and generally are isolated to specific microenvironments in vivo. Though many reactive nitrogen oxide species are formed from chemical reactions with NO, there are several which appear to not require NO to be present, HNO and NO2. These two species have unique physiological effects and represent additional complexity to this biological picture. From this discussion, a picture can be formed concerning the possible chemical dynamics, which can be plausible in different biological mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=5644277878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5644277878&partnerID=8YFLogxK

U2 - 10.2174/1566524043359854

DO - 10.2174/1566524043359854

M3 - Article

C2 - 15579020

AN - SCOPUS:5644277878

VL - 4

SP - 723

EP - 740

JO - Current Molecular Medicine

JF - Current Molecular Medicine

SN - 1566-5240

IS - 7

ER -