The clinicopathologic spectrum of mature aggressive B cell lymphomas

Lisa M Rimsza, Stefania Pittaluga, Stephan Dirnhofer, Christiane Copie-Bergman, Laurence de Leval, Fabio Facchetti, Stefano Pileri, Andreas Rosenwald, Andrew Wotherspoon, Falko Fend

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Our understanding of mature aggressive B cell lymphomas has evolved significantly in the last years as reflected in the 2016 update of the WHO lymphoma classification. A main topic of the 2016 European Association for Haematopathology/Society of Hematopathology lymphoma workshop in Basel therefore was the clinicopathological spectrum of mature aggressive B cell lymphomas with the exception of conventional diffuse large B cell lymphoma. In this review, we summarize two sessions dedicated to “high-grade B cell lymphomas, with MYC and BCL2 and/or BCL6 rearrangements (so-called double/triple-hit lymphomas)” and “high-grade B cell lymphomas, NOS” as defined in the 2016 update of the WHO lymphoma classification, Burkitt lymphoma and related neoplasms, and terminally differentiated aggressive B cell lymphomas. One focus was on cases of Burkitt lymphoma with unusual clinical features such as spontaneous regression or association with immunosuppression, and the new provisional category of Burkitt-like lymphoma with 11q aberration. The large numbers of cases submitted for the new high-grade categories with or without genetic “double/triple hit” demonstrated the broad clinical and pathological spectrum of this group and gave ample opportunity for discussion. In this review, current definitions and our understanding of the main high-grade categories, potential problem areas, and suggestions for the immunophenotypic and genetic work-up of these neoplasms are discussed and illustrated by many interesting and challenging cases submitted to the workshop.

Original languageEnglish (US)
Pages (from-to)453-466
Number of pages14
JournalVirchows Archiv
Volume471
Issue number4
DOIs
StatePublished - Oct 1 2017
Externally publishedYes

Fingerprint

B-Cell Lymphoma
Burkitt Lymphoma
Lymphoma
Non-Hodgkin's Lymphoma
Education
Lymphoma, Large B-Cell, Diffuse
Immunosuppression
Neoplasms

Keywords

  • B cell lymphomas
  • Clinicopathologic spectrum
  • Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Rimsza, L. M., Pittaluga, S., Dirnhofer, S., Copie-Bergman, C., de Leval, L., Facchetti, F., ... Fend, F. (2017). The clinicopathologic spectrum of mature aggressive B cell lymphomas. Virchows Archiv, 471(4), 453-466. https://doi.org/10.1007/s00428-017-2199-7

The clinicopathologic spectrum of mature aggressive B cell lymphomas. / Rimsza, Lisa M; Pittaluga, Stefania; Dirnhofer, Stephan; Copie-Bergman, Christiane; de Leval, Laurence; Facchetti, Fabio; Pileri, Stefano; Rosenwald, Andreas; Wotherspoon, Andrew; Fend, Falko.

In: Virchows Archiv, Vol. 471, No. 4, 01.10.2017, p. 453-466.

Research output: Contribution to journalReview article

Rimsza, LM, Pittaluga, S, Dirnhofer, S, Copie-Bergman, C, de Leval, L, Facchetti, F, Pileri, S, Rosenwald, A, Wotherspoon, A & Fend, F 2017, 'The clinicopathologic spectrum of mature aggressive B cell lymphomas', Virchows Archiv, vol. 471, no. 4, pp. 453-466. https://doi.org/10.1007/s00428-017-2199-7
Rimsza LM, Pittaluga S, Dirnhofer S, Copie-Bergman C, de Leval L, Facchetti F et al. The clinicopathologic spectrum of mature aggressive B cell lymphomas. Virchows Archiv. 2017 Oct 1;471(4):453-466. https://doi.org/10.1007/s00428-017-2199-7
Rimsza, Lisa M ; Pittaluga, Stefania ; Dirnhofer, Stephan ; Copie-Bergman, Christiane ; de Leval, Laurence ; Facchetti, Fabio ; Pileri, Stefano ; Rosenwald, Andreas ; Wotherspoon, Andrew ; Fend, Falko. / The clinicopathologic spectrum of mature aggressive B cell lymphomas. In: Virchows Archiv. 2017 ; Vol. 471, No. 4. pp. 453-466.
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