The complex immunology of human coccidioidomycosis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

29 Citations (Scopus)

Abstract

The human immune response during coccidioidomycosis is intimately involved with the development of delayed-type hypersensitivity and cellular immunity. Sixty percent of those infected have no symptoms and benign outcome is generally associated with a specific cellular immune response to coccidioidal antigens. We have recently teased out the human pulmonary granulomatous response during coccidioidomycosis and noted that there are perigranulomatous clusters of lymphocytes consisting predominantly of B lymphocytes and CD4+ T lymphocytes. In other work, we have found that the mannose receptor as well as the toll-like receptors TLR2 and TLR4 may have a role in recognizing glycosylated coccidioidal antigens. In addition, the IL-12 receptor axis appears to be operative during antigen recognition and IL-12p40 may be the active moiety. Finally, peripheral blood mononuclear cells from persons with disseminated coccidioidomycosis are able to respond to coccidioidal antigen when it is presented by a mature monocyte-derived IL-4-generated dendritic cell (DC). These observations could be useful in the development of a human vaccine against coccidiodomycosis.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages245-258
Number of pages14
Volume1111
DOIs
StatePublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1111
ISSN (Print)00778923
ISSN (Electronic)17496632

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Immunology
Coccidioidomycosis
Allergy and Immunology
Antigens
Lymphocytes
Cellular Immunity
Interleukin-12 Receptors
Interleukin-12 Subunit p40
T-cells
Toll-Like Receptors
Delayed Hypersensitivity
Human Development
Interleukin-4
Dendritic Cells
Monocytes
Blood Cells
Blood
B-Lymphocytes
Vaccines
T-Lymphocytes

Keywords

  • Cellular immunity
  • Coccidioidomycosis
  • Human

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ampel, N. M. (2007). The complex immunology of human coccidioidomycosis. In Annals of the New York Academy of Sciences (Vol. 1111, pp. 245-258). (Annals of the New York Academy of Sciences; Vol. 1111). https://doi.org/10.1196/annals.1406.032

The complex immunology of human coccidioidomycosis. / Ampel, Neil M.

Annals of the New York Academy of Sciences. Vol. 1111 2007. p. 245-258 (Annals of the New York Academy of Sciences; Vol. 1111).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ampel, NM 2007, The complex immunology of human coccidioidomycosis. in Annals of the New York Academy of Sciences. vol. 1111, Annals of the New York Academy of Sciences, vol. 1111, pp. 245-258. https://doi.org/10.1196/annals.1406.032
Ampel NM. The complex immunology of human coccidioidomycosis. In Annals of the New York Academy of Sciences. Vol. 1111. 2007. p. 245-258. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1406.032
Ampel, Neil M. / The complex immunology of human coccidioidomycosis. Annals of the New York Academy of Sciences. Vol. 1111 2007. pp. 245-258 (Annals of the New York Academy of Sciences).
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