The cyclic AMP phosphodiesterase encoded by the drosophila dunce gene is concentrated in the mushroom body neuropil

Alan J Nighorn, Marion J. Healy, Ronald L. Davis

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

Drosophila dunce (dnc) flies are defective in learning and memory as a result of lesions in the gene that codes for a CAMP-specific phosphodiesterase (PDE). Antibodies to the dnc PDE showed that the most intensely stained regions in the adult brain were the mushroom body neuropil-areas previously implicated in learning and memory. In situ hybridization demonstrated that dnc RNA was enriched in the mushroom body perikarya. The mushroom bodies of third instar larval brains were also stained intensely by the antibody, suggesting that the dnc PDE plays an important role in these neurons throughout their development. The role of the dnc PDE in mushroom body physiology is discussed, and a circuit model describing a possible role of the mushroom bodies in mediating olfactory learning and memory is presented.

Original languageEnglish (US)
Pages (from-to)455-467
Number of pages13
JournalNeuron
Volume6
Issue number3
DOIs
StatePublished - 1991
Externally publishedYes

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Mushroom Bodies
Neuropil
Phosphoric Diester Hydrolases
Cyclic AMP
Drosophila
Genes
Learning
3',5'-Cyclic-AMP Phosphodiesterases
Antibodies
Brain
Diptera
In Situ Hybridization
RNA
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The cyclic AMP phosphodiesterase encoded by the drosophila dunce gene is concentrated in the mushroom body neuropil. / Nighorn, Alan J; Healy, Marion J.; Davis, Ronald L.

In: Neuron, Vol. 6, No. 3, 1991, p. 455-467.

Research output: Contribution to journalArticle

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