The dichotomy of p53 regulation by noncoding RNAs

Qipan Deng, Lindsey Becker, Xiaodong Ma, Xiaoming Zhong, Ken Young, Kenneth Ramos, Yong Li

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

The p53 tumor suppressor gene is the most frequently mutated gene in cancer. Significant progress has been made to discern the importance of p53 in coordinating cellular responses to DNA damage, oncogene activation, and other stresses. Noncoding RNAs are RNA molecules functioning without being translated into proteins. In this work, we discuss the dichotomy of p53 regulation by noncoding RNAs with four unconventional questions. First, is overexpression of microRNAs responsible for p53 inactivation in the absence of p53 mutation? Second, are there somatic mutations in the noncoding regions of the p53 gene? Third, is there a germline mutant in the noncoding regions of the p53 gene that predisposes carriers to cancer? Fourth, can p53 activation mediated by a noncoding RNA mutation cause cancer? This work highlights the prominence of noncoding RNAs in p53 dysregulation and tumorigenesis.

Original languageEnglish (US)
Pages (from-to)198-205
Number of pages8
JournalJournal of Molecular Cell Biology
Volume6
Issue number3
DOIs
StatePublished - Jun 2014

Keywords

  • 3′UTR
  • activation
  • mutation
  • noncoding RNA
  • p53
  • polymorphism
  • ribosomopathies

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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