The druze: A population genetic refugium of the Near East

Liran I. Shlush, Doron M. Behar, Guennady Yudkovsky, Alan Templeton, Yarin Hadid, Fuad Basis, Michael F Hammer, Shalev Itzkovitz, Karl Skorecki

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Phylogenetic mitochondrial DNA haplogroups are highly partitioned across global geographic regions. A unique exception is the X haplogroup, which has a widespread global distribution without major regions of distinct localization. Principal Findings: We have examined mitochondrial DNA sequence variation together with Y-chromosome-based haplogroup structure among the Druze, a religious minority with a unique socio-demographic history residing in the Near East. We observed a striking overall pattern of heterogeneous parental origins, consistent with Druze oral tradition, together with both a high frequency and a high diversity of the mitochondrial DNA (mtDNA) X haplogroup within a confined regional subpopulation. Furthermore demographic modeling indicated low migration rates with nearby populations. Conclusions: These findings were enabled through the use of a paternal kindred based sampling approach, and suggest that the Galilee Druze represent a population isolate, and that the combination of a high frequency and diversity of the mtDNA X haplogroup signifies a phylogenetic refugium, providing a sample snapshot of the genetic landscape of the Near East prior to the modern age.

Original languageEnglish (US)
Article numbere2105
JournalPLoS One
Volume3
Issue number5
DOIs
StatePublished - May 7 2008

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Middle East
Population Genetics
refuge habitats
Mitochondrial DNA
population genetics
mitochondrial DNA
demographic statistics
Demography
Y Chromosome
DNA sequences
phylogeny
Y chromosome
Chromosomes
Population
mouth
Sampling
nucleotide sequences
sampling
history
Refugium

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Shlush, L. I., Behar, D. M., Yudkovsky, G., Templeton, A., Hadid, Y., Basis, F., ... Skorecki, K. (2008). The druze: A population genetic refugium of the Near East. PLoS One, 3(5), [e2105]. https://doi.org/10.1371/journal.pone.0002105

The druze : A population genetic refugium of the Near East. / Shlush, Liran I.; Behar, Doron M.; Yudkovsky, Guennady; Templeton, Alan; Hadid, Yarin; Basis, Fuad; Hammer, Michael F; Itzkovitz, Shalev; Skorecki, Karl.

In: PLoS One, Vol. 3, No. 5, e2105, 07.05.2008.

Research output: Contribution to journalArticle

Shlush, LI, Behar, DM, Yudkovsky, G, Templeton, A, Hadid, Y, Basis, F, Hammer, MF, Itzkovitz, S & Skorecki, K 2008, 'The druze: A population genetic refugium of the Near East', PLoS One, vol. 3, no. 5, e2105. https://doi.org/10.1371/journal.pone.0002105
Shlush LI, Behar DM, Yudkovsky G, Templeton A, Hadid Y, Basis F et al. The druze: A population genetic refugium of the Near East. PLoS One. 2008 May 7;3(5). e2105. https://doi.org/10.1371/journal.pone.0002105
Shlush, Liran I. ; Behar, Doron M. ; Yudkovsky, Guennady ; Templeton, Alan ; Hadid, Yarin ; Basis, Fuad ; Hammer, Michael F ; Itzkovitz, Shalev ; Skorecki, Karl. / The druze : A population genetic refugium of the Near East. In: PLoS One. 2008 ; Vol. 3, No. 5.
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