The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

Jeyaprakashnarayanan Seenisamy, Evonne M. Rezler, Tiffanie J. Powell, Denise Tye, Vijay Gokhale, Chandana Sharma Joshi, Adam Siddiqui-Jain, Laurence H. Hurley

Research output: Contribution to journalArticle

296 Scopus citations

Abstract

The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.

Original languageEnglish (US)
Pages (from-to)8702-8709
Number of pages8
JournalJournal of the American Chemical Society
Volume126
Issue number28
DOIs
StatePublished - Jul 21 2004

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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