The effect of a rate controlling membrane on release from polyhema hydrogels

E. J. Pywell, Samuel H Yalkowsky, J. H. Collett

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The possibility of laminating a non-permeable, perforated membrane onto a polymer matrix providing zero-order drug release kinetics has been reported. The work we have undertaken involves an assessment of the suitability of poly(2-hydroxyethylmethacrylate) (polyHEMA) as the matrix in such a system. PolyHEMA hydrogels were prepared by the radiation polymerization of HEMA monomer solutions of different initial water contents. Membranes were laminated during the polymerization process. In Vitro release rates of substituted benzoic acids from laminates were determined.

Original languageEnglish (US)
Pages (from-to)1767-1775
Number of pages9
JournalDrug Development and Industrial Pharmacy
Volume12
Issue number11-13
DOIs
StatePublished - 1986

Fingerprint

Hydrogels
Polymerization
Membranes
Laminating
Benzoates
Polymer matrix
Water content
Laminates
Polymers
Pharmacokinetics
Monomers
Radiation
Kinetics
Water
Pharmaceutical Preparations
hydroxyethyl methacrylate
Drug Liberation
In Vitro Techniques

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry
  • Molecular Medicine

Cite this

The effect of a rate controlling membrane on release from polyhema hydrogels. / Pywell, E. J.; Yalkowsky, Samuel H; Collett, J. H.

In: Drug Development and Industrial Pharmacy, Vol. 12, No. 11-13, 1986, p. 1767-1775.

Research output: Contribution to journalArticle

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