The effect of a rate controlling membrane on release from polyhema hydrogels

E. J. Pywell, S. H. Yalkowsky, J. H. Collett

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The possibility of laminating a non-permeable, perforated membrane onto a polymer matrix providing zero-order drug release kinetics has been reported. The work we have undertaken involves an assessment of the suitability of poly(2-hydroxyethylmethacrylate) (polyHEMA) as the matrix in such a system. PolyHEMA hydrogels were prepared by the radiation polymerization of HEMA monomer solutions of different initial water contents. Membranes were laminated during the polymerization process. In Vitro release rates of substituted benzoic acids from laminates were determined.

Original languageEnglish (US)
Pages (from-to)1767-1775
Number of pages9
JournalDrug Development and Industrial Pharmacy
Volume12
Issue number11-13
DOIs
StatePublished - Jan 1 1986

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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