The effect of alcohol consumption on nutritional status during murine AIDS

Yuejian Wang, Bailin Liang, Ronald R Watson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

As alcohol (ETOH) abusers and AIDS patients have nutritional disorders, the influence of chronic ETOH consumption (5% v/v for 10 weeks) on levels of immunomodulatory nutrients (vitamins A and E, Zn, and Cu) in the serum, liver, small intestine, spleen, and thymus was determined during murine AIDS. The hepatic levels of vitamins A and E and Zn in both normal and LP-BM5 retrovirus-infected female C56BL/6 mice fed ETOH were significantly reduced compared to controls, whereas the level of Cu in the liver was not affected. Intestinal levels of vitamin A and Cu were not affected by ETOH, whereas vitamin E and Zn were significantly reduced in both normal mice and those with AIDS fed ETOH. The splenic levels of vitamin A and Zn in the normal mice were significantly reduced by ETOH compared to controls, but vitamin E and Cu were not. All splenic levels of nutrients measured were reduced in ETOH-fed mice with AIDS. The levels of vitamins A and E, Zn, and Cu in the thymus in murine AIDS were also significantly affected by ETOH consumption. The serum levels of vitamins A and E in both normal mice and murine AIDS were significantly decreased by dietary ETOH. These data produced evidence that chronic ETOH can directly aggravate undernutrition initiated by retrovirus infection. Such ETOH-induced malnutrition in AIDS may be a cofactor, accelerating development of AIDS via immunosuppression secondary to nutritional deficiencies.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalAlcohol
Volume11
Issue number3
DOIs
StatePublished - 1994

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Murine Acquired Immunodeficiency Syndrome
Nutritional Status
alcohol consumption
Vitamin A
Vitamin E
Alcohol Drinking
AIDS
Alcohols
Acquired Immunodeficiency Syndrome
Malnutrition
Thymus
Liver
Thymus Gland
Nutrients
Retroviridae Infections
Nutrition Disorders
Food
Retroviridae
Serum
Immunosuppression

Keywords

  • Alcohol
  • Copper and zinc
  • Murine AIDS
  • Vitamins A and E

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

The effect of alcohol consumption on nutritional status during murine AIDS. / Wang, Yuejian; Liang, Bailin; Watson, Ronald R.

In: Alcohol, Vol. 11, No. 3, 1994, p. 273-278.

Research output: Contribution to journalArticle

Wang, Yuejian ; Liang, Bailin ; Watson, Ronald R. / The effect of alcohol consumption on nutritional status during murine AIDS. In: Alcohol. 1994 ; Vol. 11, No. 3. pp. 273-278.
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