The effect of bovine lactoferrin on muscle growth in vivo and in vitro

J. C. Byatt, J. J. Schmuke, P. G. Comens, D. A. Johnson, R. J. Collier

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Lactoferrin was found to be a potent stimulator of proliferation for L6 myoblasts. Both apo and holo-forms of lactoferrin were equipotent. By contrast, only the holo-form of transferrin (a structurally related iron binding protein) stimulated proliferation, apo-transferrin was without activity. Holo-transferrin was also less stimulatory than lactoferrin. Purified lactoferrin was administered to mature female rats and to neonatal rats by daily subcutaneous injection to determine if there was a measurable effect on muscle cell growth in vivo. Results from the in vivo studies suggest that lactoferrin has little or no effect on muscle cell growth in the whole animal.

Original languageEnglish (US)
Pages (from-to)548-553
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume173
Issue number2
DOIs
StatePublished - Dec 14 1990

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The effect of bovine lactoferrin on muscle growth in vivo and in vitro'. Together they form a unique fingerprint.

Cite this