The effect of chronic digitalization on pump function in systolic heart failure

Constantine A. Hassapoyannes, Bruce M. Easterling, Kiran Chavda, Krina K. Chavda, Mohammad R Movahed, Gary W. Welch

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Short- and intermediate-term use of cardiac glycosides promotes inotropy and improves the ejection fraction in systolic heart failure. Aim: To determine whether chronic digitalization alters left ventricular function and performance. Methods: Eighty patients with mild-to-moderate systolic heart failure (baseline ejection fraction ≤ 45%) participated from our institution in a multi-center, chronic, randomized, double-blind study of digitalis vs. placebo. Of the 40 survivors, 38 (20 allocated to the digitalis arm and 18 to the placebo arm) were evaluated at the end of follow-up (mean, 48.4 months). Left ventricular systolic function was assessed by both nuclear ventriculography and echocardiography. The ejection fraction was measured scintigraphically, while the ventricular volumes were computed echocardiographically. Results: The groups did not differ, at baseline or end-of-study, with respect to the ejection fraction and the loading conditions (arterial pressure, ventricular volumes and heart rate) by either intention-to-treat or actual-treatment-received analysis. Over the course of the trial, the digitalis arm exhibited no significant increase in the use of diuretics (18%, P = 0.33), in distinction from the placebo group (78%, P = 0.004), and a longer stay on study drug among those patients who withdrew from double-blind treatment (28.6 vs. 11.4 months, P = 0.01). Conclusion: Following chronic use of digitalis for mild-to-moderate heart failure, cross-sectional comparison with a control group from the same inception cohort showed no appreciable difference in systolic function or performance. Thus, the suggested clinical benefit cannot be explained by an inotropic effect.

Original languageEnglish (US)
Pages (from-to)593-599
Number of pages7
JournalEuropean Journal of Heart Failure
Volume3
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Systolic Heart Failure
Digitalis
Placebos
Left Ventricular Function
Cardiac Glycosides
Double-Blind Method
Diuretics
Survivors
Echocardiography
Arterial Pressure
Heart Failure
Heart Rate
Control Groups
Therapeutics
Pharmaceutical Preparations

Keywords

  • Congestive
  • Digitalis
  • Heart failure
  • Systole
  • Ventricular dysfunction, left

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The effect of chronic digitalization on pump function in systolic heart failure. / Hassapoyannes, Constantine A.; Easterling, Bruce M.; Chavda, Kiran; Chavda, Krina K.; Movahed, Mohammad R; Welch, Gary W.

In: European Journal of Heart Failure, Vol. 3, No. 5, 2001, p. 593-599.

Research output: Contribution to journalArticle

Hassapoyannes, Constantine A. ; Easterling, Bruce M. ; Chavda, Kiran ; Chavda, Krina K. ; Movahed, Mohammad R ; Welch, Gary W. / The effect of chronic digitalization on pump function in systolic heart failure. In: European Journal of Heart Failure. 2001 ; Vol. 3, No. 5. pp. 593-599.
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abstract = "Background: Short- and intermediate-term use of cardiac glycosides promotes inotropy and improves the ejection fraction in systolic heart failure. Aim: To determine whether chronic digitalization alters left ventricular function and performance. Methods: Eighty patients with mild-to-moderate systolic heart failure (baseline ejection fraction ≤ 45{\%}) participated from our institution in a multi-center, chronic, randomized, double-blind study of digitalis vs. placebo. Of the 40 survivors, 38 (20 allocated to the digitalis arm and 18 to the placebo arm) were evaluated at the end of follow-up (mean, 48.4 months). Left ventricular systolic function was assessed by both nuclear ventriculography and echocardiography. The ejection fraction was measured scintigraphically, while the ventricular volumes were computed echocardiographically. Results: The groups did not differ, at baseline or end-of-study, with respect to the ejection fraction and the loading conditions (arterial pressure, ventricular volumes and heart rate) by either intention-to-treat or actual-treatment-received analysis. Over the course of the trial, the digitalis arm exhibited no significant increase in the use of diuretics (18{\%}, P = 0.33), in distinction from the placebo group (78{\%}, P = 0.004), and a longer stay on study drug among those patients who withdrew from double-blind treatment (28.6 vs. 11.4 months, P = 0.01). Conclusion: Following chronic use of digitalis for mild-to-moderate heart failure, cross-sectional comparison with a control group from the same inception cohort showed no appreciable difference in systolic function or performance. Thus, the suggested clinical benefit cannot be explained by an inotropic effect.",
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AU - Hassapoyannes, Constantine A.

AU - Easterling, Bruce M.

AU - Chavda, Kiran

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AU - Movahed, Mohammad R

AU - Welch, Gary W.

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N2 - Background: Short- and intermediate-term use of cardiac glycosides promotes inotropy and improves the ejection fraction in systolic heart failure. Aim: To determine whether chronic digitalization alters left ventricular function and performance. Methods: Eighty patients with mild-to-moderate systolic heart failure (baseline ejection fraction ≤ 45%) participated from our institution in a multi-center, chronic, randomized, double-blind study of digitalis vs. placebo. Of the 40 survivors, 38 (20 allocated to the digitalis arm and 18 to the placebo arm) were evaluated at the end of follow-up (mean, 48.4 months). Left ventricular systolic function was assessed by both nuclear ventriculography and echocardiography. The ejection fraction was measured scintigraphically, while the ventricular volumes were computed echocardiographically. Results: The groups did not differ, at baseline or end-of-study, with respect to the ejection fraction and the loading conditions (arterial pressure, ventricular volumes and heart rate) by either intention-to-treat or actual-treatment-received analysis. Over the course of the trial, the digitalis arm exhibited no significant increase in the use of diuretics (18%, P = 0.33), in distinction from the placebo group (78%, P = 0.004), and a longer stay on study drug among those patients who withdrew from double-blind treatment (28.6 vs. 11.4 months, P = 0.01). Conclusion: Following chronic use of digitalis for mild-to-moderate heart failure, cross-sectional comparison with a control group from the same inception cohort showed no appreciable difference in systolic function or performance. Thus, the suggested clinical benefit cannot be explained by an inotropic effect.

AB - Background: Short- and intermediate-term use of cardiac glycosides promotes inotropy and improves the ejection fraction in systolic heart failure. Aim: To determine whether chronic digitalization alters left ventricular function and performance. Methods: Eighty patients with mild-to-moderate systolic heart failure (baseline ejection fraction ≤ 45%) participated from our institution in a multi-center, chronic, randomized, double-blind study of digitalis vs. placebo. Of the 40 survivors, 38 (20 allocated to the digitalis arm and 18 to the placebo arm) were evaluated at the end of follow-up (mean, 48.4 months). Left ventricular systolic function was assessed by both nuclear ventriculography and echocardiography. The ejection fraction was measured scintigraphically, while the ventricular volumes were computed echocardiographically. Results: The groups did not differ, at baseline or end-of-study, with respect to the ejection fraction and the loading conditions (arterial pressure, ventricular volumes and heart rate) by either intention-to-treat or actual-treatment-received analysis. Over the course of the trial, the digitalis arm exhibited no significant increase in the use of diuretics (18%, P = 0.33), in distinction from the placebo group (78%, P = 0.004), and a longer stay on study drug among those patients who withdrew from double-blind treatment (28.6 vs. 11.4 months, P = 0.01). Conclusion: Following chronic use of digitalis for mild-to-moderate heart failure, cross-sectional comparison with a control group from the same inception cohort showed no appreciable difference in systolic function or performance. Thus, the suggested clinical benefit cannot be explained by an inotropic effect.

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KW - Ventricular dysfunction, left

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