The effect of cobra venom factor on alternative pathway hemolytic activity in mice

K. A. Joiner, A. Hawiger, J. A. Celfand

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The in vivo effect of cobra venom factor (CVF) on murine alternative complement pathway hemolytic activity was measured with a recently developed microassay. Four different dosage schedules of CVF were compared. Hemolytic titers were lowered to less than 5% of the baseline value by 6 hours after the first dose of CVF (62.5 - 200 U/kg), and remained low for 3-5 days, depending upon total dose, route and schedule of CVF administration. Titers at days 6-9 after initial CVF injection increased above baseline in animals given two doses of CVF separated by 48 hours.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalImmunological Investigations
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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