The effect of oxygen free radical scavengers on the recovery of regional myocardial function after acute coronary occlusion and surgical reperfusion

Farid - Gharagozloo, F. J. Melendez, R. A. Hein, R. E. Austin, R. J. Shemin, V. J. DiSesa, L. H. Cohn

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study investigated the effects of the exygen free radical scavengers superoxide dismutase and catalase, the peroxide ion inhibitor, in crystalloid potassium cardioplegic solution on infarct size and global and regional myocardial function after occlusion of the left anterior descending artery and surgical reperfusion in young sheep on cardiopulmonary bypass. After 1 hour of occlusion, the animals were randomized to receive either routing potassium cardioplegia or cardioplegia with superoxide dismutase and catalase. Global hemodynamics measured by maximum rate of pressure rise showed significant improvement after 5 hours or reperfusion in the group treated with superoxide dismutase and catalase (1843 ± 163 versus 979 ± 192, p < 0.001). Regional myocardial function was measured by ultrasonic crystals, implanted in the ischemica area and in a nonischemic control segment. The percent systolic shortening or bulging was calculated. At end of reperfusion in the animals treated with superoxide dismutase and catalase, there was active shortening in the ischemic area after reperfusion of +9.2% ± 0.4% versus 2.1% ± 0.8% in untreated animals (p <0.001). Infarct size measured by triphenyltetrazolium chloride staining showed significant difference (p < 0.001) between animals treated with superoxide dismutase and catalase (0.9% ± 0.1%) and control animals (61% ± 70%). Superoxide dismutase and catalase given in the cardioplegic solution before reperfusion of an acutely ischemic area of myocardium enhances recovery of contractile function and results in a significant reduction in infarct size, which suggests improved salvage of the ischemic myocardium.

Original languageEnglish (US)
Pages (from-to)631-636
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume95
Issue number4
StatePublished - 1988
Externally publishedYes

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Free Radical Scavengers
Coronary Occlusion
Catalase
Superoxide Dismutase
Reperfusion
Reactive Oxygen Species
Induced Heart Arrest
Myocardium
Cardioplegic Solutions
Recovery of Function
Peroxides
Cardiopulmonary Bypass
Ultrasonics
Sheep
Potassium
Arteries
Hemodynamics
Ions
Staining and Labeling
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

The effect of oxygen free radical scavengers on the recovery of regional myocardial function after acute coronary occlusion and surgical reperfusion. / Gharagozloo, Farid -; Melendez, F. J.; Hein, R. A.; Austin, R. E.; Shemin, R. J.; DiSesa, V. J.; Cohn, L. H.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 95, No. 4, 1988, p. 631-636.

Research output: Contribution to journalArticle

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AU - Melendez, F. J.

AU - Hein, R. A.

AU - Austin, R. E.

AU - Shemin, R. J.

AU - DiSesa, V. J.

AU - Cohn, L. H.

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