The effect of pH and complexation of amino acid functionality on the redox chemistry of methionine and X-Ray structure of [Co(en)2(L-Met)](ClO4)2.H2O

Sanaullah, George S. Wilson, Richard S. Glass

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Anodic oxidation of methionine under different pH conditions is reported. The results are compared with the oxidation process when the glycinic terminus of methionine is coordinated with Co(III). Synthesis of [Co(en)2(L-Met)](ClO4)2, [Co(trien)(L-Met)](CF3SO3)2, and [Co(trien)(OSO2CF3)2]CF3SO3 is reported where L-Met = L-methionine, en = ethylenediamine, trien = triethylenetetraamine. The triflato complex ([Co(trien)(OSO2CF3)2]CF3SO3) can serve as a starting material for synthesizing a variety of complexes. The x-ray structure of [Co(en)2(L-Met)](ClO4)2.H2O is also presented The complex crystallizes in space group P21 of the mono-clinic system with two independent molecules in the crystallographic asymmetric unit. The unit cell dimensions are a = 9.582 (2) Å, b = 11.554 (2) Å, c = 19.988 (6) Å, and f = 98.85 (2)°. The two molecular units are related by a pseudo-center of symmetry. The electrochemical data presented here suggest a major role of the neighboring group and pH in defining the ease of oxidation of methionine.

Original languageEnglish (US)
Pages (from-to)87-99
Number of pages13
JournalJournal of Inorganic Biochemistry
Volume55
Issue number2
DOIs
StatePublished - Aug 1 1994

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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