The influence of polyhexamethyleneguanidine (PMG) on some indices of polyamine metabolism in liver and tumor tissue of rats with transplantable hepatoma H-27 as well as the plasma membrane fraction of these cells was studied. It has been established that ornithindecarboxylase (ODC) activity and polyamine content in hepatoma tissue considerably exceeded those one in the liver of tumorbearing rats and in the liver of intact animals. The ODC activity and polyamine level in liver and tumor tissue decreased after PMG administration. Under the chosen regime of PMG administration 2-fold decrease of ODC activity and the decrease of polyamine level along with 3-fold increase in γ-glutamyltranspeptidase activity were observed. Possible mechanisms of PMG antitumor effect are discussed.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jan 1 1994|
ASJC Scopus subject areas
- Cancer Research