The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin

David E. Nix, W. A. Watson, L. Handy, R. W. Frost, D. L. Rescott, H. R. Goldstein

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Based on the results of our study of norfloxacin-sucralfate coadministration, we suspected that sucralfate would interact also with ciprofloxacin if the drugs were administered concurrently. Therefore, we decided to give a 1-g dose of sucralfate at 6 and 2 hours before a single 750-mg dose of ciprofloxacin and evaluate its effect on the bioavailability of ciprofloxacin. Twelve healthy, male volunteers received ciprofloxacin alone and with sucralfate pretreatment in a randomized, balanced, crossover design. Blood and urine samples were collected over 24 hours after ciprofloxacin administration, and drug concentrations were assayed by high-performance liquid chromatography. When sucralfate was given at 6 and 2 hours before ciprofloxacin, an average 30% decrease in ciprofloxacin, an average 30% decrease in ciprofloxacin's bioavailability was noted (p < 0.05). Four of the 12 subjects, however, had decreases in the agent's area under the curve of more than 50% with sucralfate pretreatment. The results of this study suggest that ciprofloxacin and sucralfate should not be administered concurrently until a dosing interval is found that will avoid this potential interaction.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalPharmacotherapy
Volume9
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Sucralfate
Ciprofloxacin
Pharmacokinetics
Biological Availability
Norfloxacin
Pharmaceutical Preparations
Cross-Over Studies
Area Under Curve
Healthy Volunteers
High Pressure Liquid Chromatography
Urine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Nix, D. E., Watson, W. A., Handy, L., Frost, R. W., Rescott, D. L., & Goldstein, H. R. (1989). The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin. Pharmacotherapy, 9(6), 377-380.

The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin. / Nix, David E.; Watson, W. A.; Handy, L.; Frost, R. W.; Rescott, D. L.; Goldstein, H. R.

In: Pharmacotherapy, Vol. 9, No. 6, 1989, p. 377-380.

Research output: Contribution to journalArticle

Nix, DE, Watson, WA, Handy, L, Frost, RW, Rescott, DL & Goldstein, HR 1989, 'The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin', Pharmacotherapy, vol. 9, no. 6, pp. 377-380.
Nix DE, Watson WA, Handy L, Frost RW, Rescott DL, Goldstein HR. The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin. Pharmacotherapy. 1989;9(6):377-380.
Nix, David E. ; Watson, W. A. ; Handy, L. ; Frost, R. W. ; Rescott, D. L. ; Goldstein, H. R. / The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin. In: Pharmacotherapy. 1989 ; Vol. 9, No. 6. pp. 377-380.
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