Vliianie pleǐotropnogo deǐstviia odnolokusnoǐ (pp) i dvulokusnoǐ (aapp) mutatsiǐ genov okraski norok na metabolizm serotonina v mozge.

Translated title of the contribution: The effect of the pleiotropic action of single-locus (pp) and dual-locus (aapp) mutation of mink fur color genes on serotonin metabolism in the brain

N. K. Popova, N. N. Voǐtenko, A. V. Kulikov, E. M. Nikulina, G. B. Vishnevetskaia, O. V. Trapezov

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Specific features of serotonin (5-hydroxytryptamine, 5-HT) metabolism were studied in the brain of mutant sapphire minks, homozygous at genes determining silver-blue and Aleutian fur color (ppaa), and silver-blue minks (pp) in comparison with the standard-colored minks (++/++). In the midbrain of sapphire mutants, the activities of tryptophan hydroxylase (TPH) and monoamine oxidase (MAO), key enzymes of 5-HT biosynthesis and catabolism, were significantly higher; an increase in the 5-HT level was statistically nonsignificant due to considerable variation in this parameter; and the level of 5-hydroxyindole-3-acetic acid remained unchanged. A similar increase in TPH and MAO activities was also found in the midbrain of silver-blue pp minks, suggesting that activation of key enzymes of 5-HT metabolism in sapphire aapp minks is associated with the mutant alleles pp.

Translated title of the contributionThe effect of the pleiotropic action of single-locus (pp) and dual-locus (aapp) mutation of mink fur color genes on serotonin metabolism in the brain
Original languageRussian
Pages (from-to)1513-1515
Number of pages3
JournalGenetika
Volume30
Issue number11
StatePublished - Nov 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Popova, N. K., Voǐtenko, N. N., Kulikov, A. V., Nikulina, E. M., Vishnevetskaia, G. B., & Trapezov, O. V. (1994). Vliianie pleǐotropnogo deǐstviia odnolokusnoǐ (pp) i dvulokusnoǐ (aapp) mutatsiǐ genov okraski norok na metabolizm serotonina v mozge. Genetika, 30(11), 1513-1515.