Vliianie pleǐotropnogo deǐstviia odnolokusnoǐ (pp) i dvulokusnoǐ (aapp) mutatsiǐ genov okraski norok na metabolizm serotonina v mozge.

Translated title of the contribution: The effect of the pleiotropic action of single-locus (pp) and dual-locus (aapp) mutation of mink fur color genes on serotonin metabolism in the brain

N. K. Popova, N. N. Voǐtenko, A. V. Kulikov, Ella M Nikulina, G. B. Vishnevetskaia, O. V. Trapezov

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Specific features of serotonin (5-hydroxytryptamine, 5-HT) metabolism were studied in the brain of mutant sapphire minks, homozygous at genes determining silver-blue and Aleutian fur color (ppaa), and silver-blue minks (pp) in comparison with the standard-colored minks (++/++). In the midbrain of sapphire mutants, the activities of tryptophan hydroxylase (TPH) and monoamine oxidase (MAO), key enzymes of 5-HT biosynthesis and catabolism, were significantly higher; an increase in the 5-HT level was statistically nonsignificant due to considerable variation in this parameter; and the level of 5-hydroxyindole-3-acetic acid remained unchanged. A similar increase in TPH and MAO activities was also found in the midbrain of silver-blue pp minks, suggesting that activation of key enzymes of 5-HT metabolism in sapphire aapp minks is associated with the mutant alleles pp.

Original languageUndefined/Unknown
Pages (from-to)1513-1515
Number of pages3
JournalGenetika
Volume30
Issue number11
Publication statusPublished - Nov 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

Cite this

Popova, N. K., Voǐtenko, N. N., Kulikov, A. V., Nikulina, E. M., Vishnevetskaia, G. B., & Trapezov, O. V. (1994). Vliianie pleǐotropnogo deǐstviia odnolokusnoǐ (pp) i dvulokusnoǐ (aapp) mutatsiǐ genov okraski norok na metabolizm serotonina v mozge. Genetika, 30(11), 1513-1515.