The effect of the reproductive system on mutation load

Research output: Contribution to journalArticle

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Abstract

J. B. S. Haldane (Amer. Nat. 71, 337-349, 1937) argued that, in equilibrium populations, the effect of deleterious mutation on average fitness depends primarily on the mutation rate and is independent of the severity of the mutations. Specifically, the equilibrium population fitness is e-μH, where μH is the haploid genomic mutation rate. Here we extend Haldane's result to a variety of reproductive systems. Using an analysis based on the frequency of classes of individuals with a specified number of mutations, we show that Haldane's principle holds exactly for haploid sex, haploid apomixis, and facultative haploid sex. In the cases of diploid automixis with terminal fusion, diploid automixis with central fusion, and diploid selfing, Haldane's principle holds exactly for recessive mutations and approximately for mutations with some heterozygous effect. In the cases of K-ploid apomixis, diploid endomitosis, and haplodiploidy, we show that Haldane's principle holds exactly for recessive lethal mutations. In addition we extend Haldane's result to various mixtures of the above-mentioned reproductive systems. In the case of diploid out-crossing sexuals, we do not obtain an exact analytic result, but present arguments and computer simulations which show that Haldane's result extends to this case as well in the limit as the number of loci becomes large. Although diverse reproductive systems are equally fit at equilibrium, different reproductive systems harbor vastly different numbers of recessive genes at equilibrium and we provide estimates of these numbers. These different numbers of mutations may create transient selective pressures on individuals with reproductive systems different from that of the equilibrium population.

Original languageEnglish (US)
Pages (from-to)243-265
Number of pages23
JournalTheoretical Population Biology
Volume33
Issue number3
DOIs
StatePublished - 1988

Fingerprint

reproductive system
mutation
Diploidy
Haploidy
Mutation
Apomixis
diploidy
haploidy
Parthenogenesis
apomixis
Mutation Rate
Population
Recessive Genes
fitness
effect
endopolyploidy
Computer Simulation
outcrossing
gender
recessive genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Ecology, Evolution, Behavior and Systematics

Cite this

The effect of the reproductive system on mutation load. / Hopf, Frederic A.; Michod, Richard E; Sanderson, Michael.

In: Theoretical Population Biology, Vol. 33, No. 3, 1988, p. 243-265.

Research output: Contribution to journalArticle

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